Evidence map›Paper›PMID 39630884›Full record

ArticleScience translational medicine2024

Joseph Polex-Wolf, Kristine Deibler, Wouter Frederik Johan Hogendorf, Sarah Bau, Tine Glendorf, Carsten Enggaard Stidsen, Christian Wenzel Tornøe, Dong Tiantang, Sofia Lundh, Charles Pyke and 7 more

Abstract read
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Mechanisms of glucagon-like-peptide 1 in the brain beyond metabolic effects.Annals of pediatric endocrinology & metabolism · 2025
    Article
  13. Review
  14. Review
  15. Observational
  16. Review
  17. Pairing up with GLP-1 to combat obesity.Nature reviews. Drug discovery · 2025
    Article
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Joseph Polex-WolfGlobal Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0002-0441-8872
Kristine DeiblerNovo Nordisk Research Center Seattle, Novo Nordisk A/S, 530 Fairview Ave N #5000, Seattle, WA 98109, USA.ORCID 0000-0002-2376-8456
Wouter Frederik Johan HogendorfGlobal Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0003-3231-5325
Sarah BauGlobal Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0002-2873-7974
Tine GlendorfGlobal Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.
Carsten Enggaard StidsenGlobal Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0002-6636-3600
Christian Wenzel TornøeGlobal Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0002-6549-1213
Dong TiantangNovo Nordisk Research Center China, Novo Nordisk A/S, Shengmingyuan West Ring Rd, Changping District, Beijing, 102206 China.
Sofia LundhGlobal Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0002-4552-0312
Charles PykeGlobal Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.
Abigail J TomlinsonDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4192-9639
Stace KernodleDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Irwin Jack MagrissoDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0008-7830-3083
Kilian W Conde-FrieboesGlobal Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0001-5303-4448
Martin G MyersDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9468-2046
Lotte Bjerre KnudsenChief Scientific Advisor Office, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.ORCID 0000-0002-2439-7116
Randy J SeeleyDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3721-5625

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
Project 3: Neural mediators in the metabolic effects of Vertical Sleeve GastrectomyP01DK117821 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLSON, DAVID P · 2019 to 2023
$9.3M
MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGR01DK056731 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1999 to 2025
$6.0M
NIDDK NIH HHS P01 DK117821NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK056731
6 · The paper itself

Abstract

Glucagon-like peptide-1 (GLP-1) and leptin signal recent feeding and long-term energy stores, respectively, and play complementary roles in the modulation of energy balance. Previous work using single-cell techniques in mice revealed the existence of a population of leptin receptor (

Indexed as

Body WeightEatingGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsLeptinNeuronsReceptors, LeptinAnimalsMaleMiceMice, Inbred C57BLGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsLeptinReceptors, Leptin

Identifiers

PMID39630884
PMCPMC12967300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.