ArticleRevista do Colegio Brasileiro de Cirurgioes2024
Cross-cultural adaptation of the Karnofsky Performance Status instrument to Brazilian Portuguese.
Article in Revista do Colegio Brasileiro de Cirurgioes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Impact of Physical Frailty on Early Intolerance to CAPOX Chemotherapy in Patients With Colon, Rectal, and Gastric Cancer.Cancer medicine · 2026Observational
- Hope and Acceptance at the End of Life: Impact of Spirituality on Patients in Palliative Care.Cureus · 2025Article
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3 authors.
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Abstract
introductionThe Karnofsky Performance Status (KPS) is one of the most widely used tools for assessing the prognosis of oncology patients, providing an estimate of treatment efficiency and survival. Despite this, it is commonly used in free translations without validation. The objective of the present study was to perform the cross-cultural adaptation of the KPS instrument to Brazilian Portuguese (KPS-BR) through the stages of conceptual, semantic, operational, measurement, and functional equivalences.
methodsTo assess consistency, we used Cronbach's alpha and kappa coefficients. The Chi-square test was performed to evaluate the association between scores and the number of deaths. The relationship with survival and mortality was explored with Kaplan-Meier curves.
resultsA total of 316 patients participated in the study. The internal consistency analysis resulted in a Cronbach's alpha coefficient of 0.9265. For the inter-rater analysis, the correlation coefficient was 1, as was the kappa coefficient, indicating perfect agreement between observers. The correlation coefficient between the KPS-BR scale in the test-retest was 0.8631. We observed a 100% death rate at KPS-BR scale score 20 and a gradual decrease as the KPS-BR scale score increases up to KPS-BR 40 (p<0.0001). Estimation of survival using the Kaplan-Meier method demonstrated an association between KPS-BR scale scores and survival (p<0.0001).
conclusionThe KPS-BR scale showed reliability and validity for the prognostic assessment of cancer patients, demonstrating a correlation with survival.
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