ArticleActa cirurgica brasileira2024
Calendula glycolic extract enhances wound healing of alginate hydrogel.
Article in Acta cirurgica brasileira, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Review
- Integrative Therapies in Wound Healing in Small Animals: An Approach Beyond Traditional Medicine.Veterinary sciences · 2026Review
- Strategies for Incorporating Natural Therapeutic Agents into Hydrogel Dressings: Innovations in Wound Healing.Polymers · 2025Review
- An Update of Phytotherapeutic Advances of Marigold (Plants (Basel, Switzerland) · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the cytotoxicity and wound healing properties of an alginate hydrogel containing calendula glycolic extract.
methodsCell viability in murine fibroblasts (3T3 cells) was evaluated using MTT and SRB assays. The wound healing effect was tested in an incisional wound model on 50 female Wistar rats, divided into two groups: rats treated with alginate hydrogel (n = 25), and rats treated with calendula-alginate hydrogel. Wound healing was assessed by measuring wound retraction rate and histological analysis of lesion tissues over a 28-day period. Histological analyses were performed on days 2, 7, 14, 21, and 28 post-surgery to examine inflammatory infiltrate, macrophage count, and angiogenesis. Picrosirius red staining was used to compare the relative abundance of collagen types I and III fibers.
resultsCytotoxicity tests on 3T3 cells revealed increased cell viability with the calendula-alginate hydrogel. The calendula-alginate hydrogel also demonstrated a significant improvement in wound closure, supported by histopathological analysis, showing reduced inflammation, increased macrophage activity, and enhanced collagen deposition.
conclusionsThese findings evidenced the therapeutic potential of combining calendula extract and alginate for promoting enhanced wound healing.
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