ArticlePloS one2024
Modulation of electrical activity of proteinoid microspheres with chondroitin sulfate clusters.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Proteinoid Computing on Olivine Substrates.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Protocell Computing on Aragonite Substrates.ACS omega · 2026Article
- Spiking Neurons Derived from Proteinoid and Bacteriorhodopsin.ACS applied bio materials · 2025Article
- Biohybrid Computing with Proteinoids and Algae.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Polymorphism in Glu-Phe-Asp Proteinoids.Biomimetics (Basel, Switzerland) · 2025Article
- On the Response of Proteinoid Ensembles to Fibonacci Sequences.ACS omega · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteinoids-thermal proteins-are produced by heating amino acids to their melting point and initiation of polymerisation to produce polymeric chains. Proteinoids swell in aqueous solution into hollow microspheres. The proteinoid microspheres produce endogenous burst of electrical potential spikes and change patterns of their electrical activity in response to illumination. These microspheres were proposed as proto-neurons in 1950s. To evaluate pathways of potential evolution of these proto-neurons and their applicability of chimera neuromorphic circuits we decided to hybridise them with hondroitin sulphate (CS) clusters, which form a part of the brain extracellular matrix. We found a novel synergistic interaction between CS clusters and proteinoids that dramatically affects patterns of electrical activity of proteinoid microspheres. Our study might shed light on evolution of synaptic plasticity's molecular mechanisms and the role of extracellular matrix-protein interactions in learning, and open up possibilities for novel methods in unconventional computing and the development of adaptable, brain-inspired computational systems.
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Registered trials
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