Evidence map›Paper›PMID 39630601›Full record

ArticleMolecular microbiology2024

Cytoadhesion of Plasmodium falciparum-Infected Red Blood Cells Changes the Expression of Cytokine-, Histone- and Antiviral Protein-Encoding Genes in Brain Endothelial Cells.

Johannes Allweier, Michael Bartels, Hanifeh Torabi, Maria Del Pilar Martinez Tauler, Nahla Galal Metwally, Thomas Roeder, Thomas Gutsmann, Iris Bruchhaus

Abstract read
In one paragraph

Article in Molecular microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Inhibition ofBiomedicines · 2025
    Article
  2. Febrile temperature enhancesbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Johannes AllweierResearch Group Host-Parasite Interaction, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-5845-5804
Michael BartelsResearch Group Host-Parasite Interaction, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Hanifeh TorabiResearch Group Host-Parasite Interaction, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Maria Del Pilar Martinez TaulerResearch Group Host-Parasite Interaction, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Nahla Galal MetwallyResearch Group Host-Parasite Interaction, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0001-9423-7145
Thomas RoederDepartment Molecular Physiology, Zoology, Kiel University, Kiel, Germany.ORCID 0000-0002-3489-3834
Thomas GutsmannDivision of Biophysics, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany.ORCID 0000-0001-5061-7891
Iris BruchhausResearch Group Host-Parasite Interaction, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.ORCID 0000-0002-3363-7409

Funding

Deutsche Forschungsgemeinschaft (SPP 2332) BR 1744/20-1Deutsche Forschungsgemeinschaft (SPP 2332) GU 568/9-1Jürgen Manchot StiftungLeibniz Center Infection
6 · The paper itself

Abstract

Malaria remains a significant global health problem, mainly due to Plasmodium falciparum, which is responsible for most fatal infections. Infected red blood cells (iRBCs) evade spleen clearance by adhering to endothelial cells (ECs), triggering capillary blockage, inflammation, endothelial dysfunction and altered vascular permeability, prompting an endothelial transcriptional response. The iRBC

Indexed as

CytokinesEndothelial CellsErythrocytesMalaria, FalciparumPlasmodium falciparumBrainCell AdhesionHistonesHumansProtozoan ProteinsSignal TransductionViral ProteinsCytokinesHistonesProtozoan ProteinsViral Proteinscytoadhesionendothelial cellsfevermalariaPlasmodium falciparumtranscriptome

Identifiers

PMID39630601
PMCPMC11658792

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.