Observational studyAIDS (London, England)2025
Predictors of frailty trajectories among people with HIV.
Observational study in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.Age and ageing · 2026Trial
- Prevalence and clinical correlates of frailty among adults with HIV infection and unhealthy alcohol or drug use.AIDS (London, England) · 2026Article
- Interventions and opportunities to enhance aging among people with HIV: a focus on frailty, sarcopenia, and intrinsic capacity.Topics in antiviral medicine · 2026Review
- Article
- Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion.The Journal of infectious diseases · 2026Article
- Frailty and All-Cause Mortality Among People With HIV Engaged in Clinical Care in the United States.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThis study aimed to estimate the latent frailty trajectories and identify corresponding predictors (sociodemographic, HIV-related, comorbidities, and behavioral) among a cohort of people with HIV (PWH).
designLongitudinal observational study using latent class growth modeling.
methodsNine hundred and seventy-six PWH aged 40 years and older with frailty measured from at least two visits within the ACTG HAILO cohort were included. Frailty components included weakness, physical activity, weight loss, exhaustion, and slowness. Latent class growth models were estimated to capture change in frailty over time; multinomial logistic regression was used to estimate associations between predictors and frailty trajectory class.
resultsAt baseline, participants were M = 51.5 years old ( SD = 7.5), 81% male ( n = 783), 48% White non-Hispanic ( n = 461), and 20% Hispanic ( n = 195). Latent class growth models identified three frailty trajectories: sustained robustness ( n = 811; 83%), worsening frailty ( n = 79; 8%), and frailty improvement ( n = 86; 9%). Older age, race, sex at birth, select comorbidities (cardiovascular disease, depression, type 2 diabetes), and behavioral characteristics (physical activity, smoking, and alcohol) were associated with fluctuations in frailty trajectories over time ( P < 0.05).
conclusionModifiable factors such as managing comorbidities and promoting physical activity present ideal opportunities for future interventions to prevent or slow the progression of frailty.
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