ArticleJournal of the American Chemical Society2024
Defect-Engineered Metal-Organic Frameworks as Bioinspired Heterogeneous Catalysts for Amide Bond Formation.
Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Spatial Orientation-Dependent Double Hydrogen Bond/Photoredox Cooperative Catalysis in Metal-Organic Frameworks.Angewandte Chemie (International ed. in English) · 2026Article
- Leveraging Conformational Dynamics of MOFs to Overcome Conversion-Selectivity Trade-Off in COAngewandte Chemie (International ed. in English) · 2026Article
- From Mineral Surfaces to Peptides: Hydroxyapatite-Based Platforms for Surface-Mediated Prebiotic Synthesis.International journal of molecular sciences · 2026Review
- Defect-Engineered MOF-808-SOMolecules (Basel, Switzerland) · 2026Article
- Porous Functional Nanomaterials for Continuous Flow Catalysis.Nano-micro letters · 2026Review
- Crafting defects in two-dimensional organic platelets via seeded coassembly enables emergent molecular recognition.Nature communications · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The synthesis of amides from amines and carboxylic acids is the most widely carried out reaction in medicinal chemistry. Yet, most amide couplings are still conducted using stoichiometric reagents, leading to significant waste; few synthetic catalysts for this transformation have been adopted industrially due to their limited scope and/or poor recyclability. The majority of catalytic approaches focus on a single activation mode, such as enhancing the electrophilicity of the carboxylic acid partner using a Lewis acid. In contrast, nature effortlessly forges and breaks amide bonds using precise arrays of Lewis/Brønsted acidic and basic functional groups. Drawing inspiration from these systems, herein we report a simple defect engineering strategy to colocalize Lewis acidic Zr sites with other catalytically active species within porous metal-organic frameworks (MOFs). Specifically, the combination of pyridine
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.