Evidence map›Paper›PMID 39630295›Full record

ArticleOral and maxillofacial surgery2024

Socket preservation following tooth extraction: an experimental study comparing β-Tricalcium phosphate and F18 bioglass in rats.

Melissa Aparecida Batoki Chad, Emanoella da Silva Cenci, Renata Klemp Orlandini, Marina Trevelin Souza, Edgar Dutra Zanotto, Gileade Pereira Freitas, Marcelo Rodrigues Azenha, Alan Grupioni Lourenço

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Oral and maxillofacial surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Melissa Aparecida Batoki ChadDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Via do Café s/n, Ribeirão Preto, 14040-900, SP, Brazil.ORCID http://orcid.org/0000-0001-5088-5482
Emanoella da Silva CenciDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Via do Café s/n, Ribeirão Preto, 14040-900, SP, Brazil.ORCID http://orcid.org/0009-0000-4660-8028
Renata Klemp OrlandiniDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Via do Café s/n, Ribeirão Preto, 14040-900, SP, Brazil.ORCID http://orcid.org/0000-0003-4002-5969
Marina Trevelin SouzaVitreous Materials Laboratory (LaMaV), Department of Materials Engineering, Federal University of São Carlos, São Carlos, SP, Brazil.ORCID http://orcid.org/0000-0002-0291-6034
Edgar Dutra ZanottoVitreous Materials Laboratory (LaMaV), Department of Materials Engineering, Federal University of São Carlos, São Carlos, SP, Brazil.ORCID http://orcid.org/0000-0003-4931-4505
Gileade Pereira FreitasDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Federal University of Goiás, Goiânia, Goiás, Brazil.ORCID http://orcid.org/0000-0002-1674-4667
Marcelo Rodrigues AzenhaDepartment of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0002-0029-7575
Alan Grupioni LourençoDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Via do Café s/n, Ribeirão Preto, 14040-900, SP, Brazil. lourenco@forp.usp.br.ORCID http://orcid.org/0000-0002-4005-157X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the efficacy of two third-generation resorbable biomaterials-F18 bioglass and β-tricalcium phosphate (β-TCP)-in promoting new bone formation in post-extraction sockets in rats. β-TCP, a synthetic porous ceramic, is well-established in clinical use, while F18 bioglass, a novel silica based bioglass.

methodsAfter extraction of the right upper incisor of 45 rats, the sockets were filled either with F18 or β-TCP, or left to naturally fill with a blood clot in control group. To quantify new bone formation, five animals from each group were euthanized at 7, 14, and 28 days post-extraction. Subsequently, the hemi-maxillae were analyzed using microtomography and histomorphometry.

resultsTwo-way ANOVA revealed significant differences in bone neoformation. β-TCP induced notably higher levels of new bone growth compared to the control group, as evidenced by microtomographic parameters such as bone volume (p = 0.033), bone surface (p = 0.039), and trabecular thickness (p = 0.002). F18 bioglass also induced higher new bone growth compared to the control group, evidenced by bone volume (p = 0.039). Although F18 bioglass did not significantly differ from the control group in other microtomographic parameters of new bone formation, its overall performance was comparable to that of β-TCP.

conclusionβ-TCP has proven to be effective in promoting new bone formation. Although F18 bioglass did not significantly differ from the control group in several microtomographic parameters, its overall capacity to promote new bone growth was comparable to that of β-TCP. This outcome supports the use of F18 bioglass as a promising alternative biomaterial for alveolar ridge preservation.

Indexed as

Calcium PhosphatesCeramicsTooth ExtractionTooth SocketX-Ray MicrotomographyAnimalsBiocompatible MaterialsBone RegenerationBone SubstitutesMaleOsteogenesisRatsRats, Wistarbeta-tricalcium phosphateBiocompatible MaterialsBioglassBone SubstitutesCalcium PhosphatesAlveolar Ridge PreservationF18 bioglassSocket preservationβ-Tricalcium Phosphate

Identifiers

PMID39630295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.