Evidence map›Paper›PMID 39630274›Full record

ArticleMikrochimica acta2024

Detection of Aβ40 in cerebrospinal fluid and plasma of Alzheimer's disease patients using photoelectrochemical biosensors.

Liting Li, Na Wei, Yiwei Guo, Xingyu Zhu, Lin Wang, Yanzhao Zhu, Ke Fang, Shenhui Ma, Yingying Zhang, Yan Zhang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liting LiDepartment of Neurology, Northwest University First Hospital, Xi'an, 710043, China.
Na WeiThe College of Life Sciences, Northwest University, Xi'an, 710068, China.
Yiwei GuoKey Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China.
Xingyu ZhuThe College of Life Sciences, Northwest University, Xi'an, 710068, China.
Lin WangKey Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China.
Yanzhao ZhuDepartment of Neurology, Northwestern University School of Medicine, Xi'an, 710068, China.
Ke FangKey Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China.
Shenhui MaKey Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China.
Yingying ZhangThe College of Life Sciences, Northwest University, Xi'an, 710068, China.
Yan ZhangThe College of Life Sciences, Northwest University, Xi'an, 710068, China.
Xiaofei ZhouThe College of Life Sciences, Northwest University, Xi'an, 710068, China.
Gang ZhaoDepartment of Neurology, Northwest University First Hospital, Xi'an, 710043, China. zhaogang@nwu.edu.cn.
Yuyu BuKey Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China. yybu@xidian.edu.cn.
Linfu ZhouDepartment of Neurology, Northwest University First Hospital, Xi'an, 710043, China. zhoelfu@nwu.edu.cn.

Funding

Shaanxi Provincial Key R&D Program - General Project - Social Development Field 2023-YBSF-339
6 · The paper itself

Abstract

An ultra-sensitive photoelectrochemical (PEC) biosensor for amyloid-beta 40 (Aβ40), a biomarker for Alzheimer's disease (AD), was developed using g-C₃N₄ modified with gold nanoparticles (Au NPs) to form Au-C₃N₄. This was further combined with TiO₂ to create a tightly bonded TiO₂/Au-C₃N₄ heterojunction, leading to a highly responsive photocatalytic process. Furthermore, the incorporation of noble metal Au NPs not only enhances photocurrent generation but also securely immobilizes the aptamer through Au-S bonds, providing additional surface binding sites. This significantly increases the sensor's capture efficiency. The sensor exhibited excellent performance, featuring a linear detection range from 10

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiosensing TechniquesElectrochemical TechniquesGoldLimit of DetectionMetal NanoparticlesPeptide FragmentsAptamers, NucleotideBiomarkersHumansPhotochemical ProcessesTitaniumAmyloid beta-Peptidesamyloid beta-protein (1-40)Aptamers, NucleotideBiomarkersGoldPeptide FragmentsTitaniumtitanium dioxideAlzheimer's diseaseAmyloid-beta 40Electrophoretic depositionG-C₃N₄Photoelectrochemical biosensorTiO₂

Identifiers

PMID39630274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.