ArticlePlant biotechnology journal2025
Single-cell RNA sequencing reveals a key regulator ZmEREB14 affecting shoot apex development and yield formation in maize.
Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Multi-Omics Frontiers in Plant Adaptation and Growth: From Molecular Networks to Precision Breeding.Plants (Basel, Switzerland) · 2026Article
- Single-cell insights into plant growth, adaptation, and evolution.Journal of integrative plant biology · 2026Review
- ZmAGA1 enhances seed germination through raffinose hydrolysis and ZmSnRK1α-mediated starch mobilization in maize.Genome biology · 2026Article
- Protein Phosphorylation: An Essential Role in Shoot Apical Meristem Homeostasis.Plants (Basel, Switzerland) · 2026Review
- Investigating the role of inflammatory bowel disease-associated gene expression in oral cancer using single-cell RNA sequencing.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Serial Spatial Transcriptomes Reveal Regulatory Transitions in Maize Leaf Development.Plant biotechnology journal · 2026Article
- Research on Bamboo Shoot Bud Development: A Leap from Tissue Heterogeneity to Single-Cell Spatial Atlas.Plants (Basel, Switzerland) · 2026Review
- Dynamic and cell-type specific transcriptional reprogramming underlies the floral transition in the maize shoot apical meristem.Genome biology · 2026Article
- Article
- Non-coding RNAs and their role in plants: prospective omics-tools for improving growth, development and stress tolerance in field crops.Molecular biology reports · 2025Review
- Single-cell RNA sequencing reveals cellular diversity and gene expression dynamics in maize root development.Frontiers in plant science · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
Shoot apical meristem (SAM) is the origin of aerial structure formation in the plant life cycle. However, the mechanisms underlying the maize SAM development are still obscure. Here, approximately 12 700 cells were captured from the 5-day-old shoot apex of maize using a high-throughput single-cell transcriptome sequencing. According to the gene expression patterns, we partitioned the cells into 8 cell types with 13 transcriptionally distinct cell clusters and traced the developmental trajectory of shoot apex. Regulatory network analysis of transcription factors (TFs) showed that three core TFs, AP2-EREBP-transcription factor 14 (ZmEREB14, Zm00001d052087), MYB histone 4 (ZmMYB4) and HSF-transcription factor 8 (ZmHSF8) potentially regulated the SAM development. Functional validation revealed that ZmEREB14 affected the SAM development and thereby regulated the maize yield formation. Our results characterised the inherent heterogeneity of SAM at single-cell resolution and provided new insights into the mechanisms of SAM development.
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