Evidence map›Paper›PMID 39629903›Full record

Observational studyPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2024

Duration of food protein-induced allergic proctocolitis (FPIAP) and the role of intestinal microbiota.

G N Vallianatou, N Douladiris, L Mageiros, E Manousakis, V Zisaki, M Galani, P Xepapadaki, S Taka, N G Papadopoulos

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Duration of food protein-induced allergic proctocolitis (FPIAP) and the role of intestinal microbiota.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

G N VallianatouAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-2346-1531
N DouladirisAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
L MageirosAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
E ManousakisAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
V ZisakiAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
M GalaniAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
P XepapadakiAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0001-9204-1923
S TakaAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
N G PapadopoulosAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-4448-3468

Funding

Diary Goat Cooperative
6 · The paper itself

Abstract

backgroundFood protein-induced allergic proctocolitis (FPIAP) is the leading cause of rectal bleeding in infants. Tolerance is presumed to develop until the first year of age, although natural history studies are scarce, making the determination of the ideal duration for any intervention, challenging. Intestinal microbiota (IM) is crucial in food allergy development; however, data for FPIAP remain limited. This study aimed to assess FPIAP remission after 3 months of milk avoidance and its correlation with IM longitudinal changes.

methodsA prospective observational study of infants aged ≤6 months with a diagnosis of FPIAP. After 3 months of management according to a clinical algorithm, infants were subjected to a milk challenge using either a cow (CM) or a goat (GM) milk formula in a random order. Stool samples were collected longitudinally for microbiome analysis.

resultsOut of 61 infants, 57 were challenged (29 with CM, 28 with GM). Of these, 55 (96.5%) achieved tolerance, with no difference in tolerance rates between CM (28/29) and GM (27/28). The average age of tolerance development was 6.3 months. Enterobacteriaceae clusters (Klebsiella- and Shigella-dominated) were most often represented in samples from symptomatic infants. In contrast, Bacteroides and Bifidobacteria clusters emerged later, in apparently healthy infants.

conclusionA 3-month intervention was sufficient for almost all infants to achieve tolerance. GM was tolerated equally well to CM. Symptomatic FPIAP is associated with immature enterotypes, while disease remission coincides with microbiome changes in time.

Indexed as

Gastrointestinal MicrobiomeMilk HypersensitivityProctocolitisAllergensAnimalsCattleFecesFemaleFood HypersensitivityGoatsHumansImmune ToleranceInfantInfant FormulaMaleProspective StudiesAllergensallergic proctocolitisenterotypesfood protein‐induced allergic proctocolitisgut microbiomeinfantsintestinal microbiotamicrobiome maturationnon‐IgE food allergyrectal bleeding

Identifiers

PMID39629903
PMCPMC11616471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.