Evidence map›Paper›PMID 39629884›Full record

ArticleChild: care, health and development2025

ADHD (Attention-Deficit Hyperactivity Disorder) Symptoms Are Associated With Chronic Pain Interference: Results From a Prospective Cohort Study.

Patrick C M Brown, Sarah W Feldstein Ewing, Anna C Wilson

Abstract read
In one paragraph

Article in Child: care, health and development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patrick C M BrownSchool of Medicine, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0003-3738-3626
Sarah W Feldstein EwingDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Anna C WilsonDepartment of Pediatrics, Institute on Development and Disability, Oregon Health & Science University, Portland, Oregon, USA.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Risk for opioid abuse and misuse in adolescenceR01DA044778 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI FELDSTEIN EWING, SARAH W., WILSON, ANNA CAMILLE · 2018 to 2022
$3.4M
NCATS NIH HHS UL1 TR002369NCATS NIH HHS UL1TR002369NIDA NIH HHS 3R01DA044778-02S1NIDA NIH HHS R01 DA044778NIDA NIH HHS R01DA044778
6 · The paper itself

Abstract

backgroundDespite a known relationship between attention-deficit hyperactivity disorder (ADHD) and chronic pain, the association between ADHD symptoms and pain interference has not been prospectively investigated.

methodsYoung adults were recruited following receipt of a prescription opioid from ambulatory surgery clinics, outpatient clinics and emergency departments as part of a larger study. Participants completed measures of ADHD symptoms, depression, pain catastrophizing, adverse childhood experiences and pain interference at enrolment and 6 months later. Logistic regression was used to examine the relationship between ADHD symptoms and covariates on moderate-to-severe pain interference at 6 months.

resultsParticipants were 116 young adults who completed the baseline ADHD symptoms measure; 71 completed the 6-month timepoint. Moderate-to-severe pain interference was present among 89.7% at baseline and 52.3% at 6 months. ADHD symptoms (OR [odds ratio] = 1.42, 95% CI [confidence interval] = 1.05-1.93), depression (OR = 1.08, 95% CI = 1.02-1.14) and pain catastrophizing (OR = 1.06, 95% CI = 1.01-1.12) were significantly associated with odds of moderate-to-severe pain interference at 6 months. In multivariable regression, ADHD symptoms (OR = 1.52, 95% CI = 1.09-2.12) and pain catastrophizing (OR = 1.07, 95% CI = 1.01-1.13) were significant predictors of moderate-to-severe pain interference at 6 months.

conclusionsParticipants with more ADHD symptoms were at greater risk for chronic pain interference. This is consistent with prior studies examining the role of attention in chronic pain. Individuals with ADHD symptoms may be at greater risk for chronic pain and future research should investigate tailored prevention and treatment approaches.

Indexed as

Attention Deficit Disorder with HyperactivityCatastrophizationChronic PainAdolescentAdultAdverse Childhood ExperiencesAnalgesics, OpioidDepressionFemaleHumansMalePain MeasurementProspective StudiesYoung AdultAnalgesics, OpioidADHDattentionchronicpainpain interference

Identifiers

PMID39629884
PMCPMC12051463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.