Evidence map›Paper›PMID 39629666›Full record

ArticleDevelopment (Cambridge, England)2024

A Pax3 lineage gives rise to transient haematopoietic progenitors.

Giovanni Canu, Rosamaria Correra, Guillermo Diez-Pinel, Raphaël F P Castellan, Laura Denti, Alessandro Fantin, Christiana Ruhrberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Insights Into Stria Vascular Function, Stria Immunity, and Age-Related Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giovanni CanuUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0002-3349-4479
Rosamaria CorreraUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
Guillermo Diez-PinelUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0002-2297-4776
Raphaël F P CastellanUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0002-6221-9185
Laura DentiUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0002-6000-5765
Alessandro FantinDepartment of Biosciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-5517-6068
Christiana RuhrbergUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0002-3212-9381

Funding

Associazione Italiana per la Ricerca sul Cancro 22905British Heart Foundation FS/19/14/34170British Heart Foundation PG/18/85/34127British Heart Foundation PG/23/11301University College LondonWellcome TrustWellcome Trust 205099/Z/16/Z
6 · The paper itself

Abstract

During embryonic development, muscle tissues, skin, and a subset of vascular endothelial cells arise from Pax3-expressing embryonic progenitors defined as paraxial mesoderm. By contrast, haemogenic potential is well established for extra-embryonic mesoderm and intra-embryonic lateral plate mesoderm, which do not express Pax3. To date, it is not known whether the haematopoietic system also contains Pax3 lineage cells. Here, we show that the mouse foetal liver and foetal circulation contain a transient population of Pax3 lineage cells with hallmarks of haematopoietic progenitors and the potential to generate both myeloid and erythroid cells. We propose that Pax3 lineage haematopoietic cells should be investigated to better understand normal haematopoietic development from different mesodermal derivatives. Further, genetic alterations of Pax3 lineage haematopoietic cells should be investigated for their potential to cause haematopoietic malignancies.

Indexed as

Cell LineageHematopoietic Stem CellsPaired Box Transcription FactorsPAX3 Transcription FactorAnimalsCell DifferentiationErythroid CellsGene Expression Regulation, DevelopmentalHematopoiesisLiverMesodermMicePaired Box Transcription FactorsPax3 protein, mousePAX3 Transcription FactorFoetal liverHematopoietic developmentMacrophage originMouseParaxial mesodermPax3Vascular endothelial cell

Identifiers

PMID39629666
PMCPMC11658681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.