Evidence map›Paper›PMID 39629588›Full record

ArticleCirculation. Cardiovascular imaging2024

Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR.

Joseph R Starnes, Jeffrey G Weiner, Kristen George-Durrett, Kimberly Crum, Christopher C Henderson, M Jay Campbell, Katheryn Gambetta, Kan N Hor, Nazia Husain, Jennifer S Li and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Epicardial Adipose Tissue in Duchenne Muscular Dystrophy Cardiomyopathy.Journal of the American Heart Association · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Joseph R StarnesDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.).ORCID 0000-0001-7954-5385
Jeffrey G WeinerDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.).ORCID 0000-0001-6851-2588
Kristen George-DurrettDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.).ORCID 0000-0001-6009-5417
Kimberly CrumDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.).ORCID 0000-0003-2112-1541
Christopher C HendersonDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.).
M Jay CampbellDivision of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC (M.J.C., J.S.L.).ORCID 0000-0002-5210-9038
Katheryn GambettaDivision of Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, IL (K.G., N.H.).
Kan N HorDivision of Cardiology, Department of Pediatrics, Nationwide Children's Hospital, Ohio State University, Columbus (K.N.H.).ORCID 0000-0003-4628-5227
Nazia HusainDivision of Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, IL (K.G., N.H.).ORCID 0000-0003-4743-2313
Jennifer S LiDivision of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC (M.J.C., J.S.L.).ORCID 0000-0002-3254-1712
Frank J RaucciDivision of Cardiology, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University (F.J.R.).ORCID 0000-0002-3464-6569
Brian D SorianoDivision of Cardiology, Department of Pediatrics, Seattle Children's Hospital, WA (B.D.S.).ORCID 0000-0002-7959-1960
Christopher F SpurneyChildren's National Heart Institute, Children's National Hospital, Washington, DC (C.F.S.).ORCID 0000-0003-2493-5735
Larry W MarkhamDivision of Cardiology, Department of Pediatrics, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis (L.W.M.).ORCID 0000-0002-2804-4641
Jonathan H SoslowDivision of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.).ORCID 0000-0001-9194-5330

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Learning Health System training program: PROgRESS--Patient/ pRactice Outcomes and Research in Effectiveness and Systems ScienceT32HS026122 · AHRQ · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G, ROUMIE, CHRISTIANNE L. · 2018 to 2024
$3.5M
Prospective Development of a Multimodal Biomaker Platform for Predictive Risk Stratification of Cardiac Disease in Duchenne Muscular DystrophyR01FD006649 · FDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOSLOW, JONATHAN HARVEY · 2019 to 2024
$2.5M
Quantitative Assessment of Cardiac Disease in Duchenne Muscular DystrophyK23HL123938 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOSLOW, JONATHAN HARVEY · 2014 to 2018
$829k
Development of a Multimodal Biomaker Platform for Predictive Risk Stratification of Cardiac Disease in Duchenne Muscular DystrophyR56HL141248 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOSLOW, JONATHAN HARVEY · 2018 to 2018
$769k
AHRQ HHS T32 HS026122FDA HHS R01 FD006649NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K23 HL123938NHLBI NIH HHS R56 HL141248
6 · The paper itself

Abstract

backgroundCardiomyopathy is the leading cause of death in boys with Duchenne muscular dystrophy (DMD). While cardiac magnetic resonance (CMR) is routinely used to assess fibrosis and left ventricular (LV) ejection fraction, CMR measures of LV filling and ejection in DMD have not been reported.

methodsPatients with DMD (n=179) and healthy controls (n=96) were prospectively enrolled and underwent CMR. The DMD cohort was followed clinically at multiple institutions, and clinical data were recorded. Standard volumes and functions were calculated, and LV filling and ejection curves were measured from baseline CMR. Multivariable linear regressions were used to compare ventricular filling and ejection measures between groups, adjusting for baseline differences. Cox regressions were used to evaluate the relationship between diastolic function measures and mortality in the DMD cohort.

resultsPatients with DMD had significantly smaller stature and ventricular volumes than healthy control patients (

conclusionsPatients with DMD have significantly different baseline CMR filling and ejection indices compared with controls. Some filling indices are associated with mortality and may be useful prognostic measures. Further research is needed in larger cohorts to determine the prognostic value of these differences.

Indexed as

DiastoleMagnetic Resonance Imaging, CineMuscular Dystrophy, DuchenneStroke VolumeVentricular Dysfunction, LeftVentricular Function, LeftAdolescentCardiomyopathiesCase-Control StudiesChildHumansMalePredictive Value of TestsPrognosisProspective StudiesRisk Factorscardiomyopathiesdiastolemagnetic resonance imagingmuscular dystrophiesprognosis

Identifiers

PMID39629588
PMCPMC11652209

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.