Observational studyCirculation. Cardiovascular imaging2024
Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement.
Observational study in Circulation. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04627987 (Mechanisms of Excess Risk in Aortic STEnosis After Aortic Valve Replacement), which is not on this map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Mechanisms of Excess Risk in Aortic STEnosis After Aortic Valve Replacement
Who cites it
6 citing papers in PubMed.
- Preoperative global longitudinal strain predicts myocardial hypertrophy burden but not the magnitude of reverse remodeling after surgical aortic valve replacement in severe aortic stenosis.Journal of cardiovascular imaging · 2026Article
- Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications.Heart failure reviews · 2026Review
- Long-Term Outcomes of Targeted Volume Overload Management in Patients With Severe Aortic Stenosis.JACC. Advances · 2026Article
- Cardiac Magnetic Resonance Imaging and Histology in Aortic Valve Disease: Convergences and Limitations.Arquivos brasileiros de cardiologia · 2026Article
- Molecular Mechanisms of Cardiac Adaptation After Device Deployment.Journal of cardiovascular development and disease · 2025Review
- Extracellular volume fraction associates with long-term outcome in patients with severe symptomatic aortic stenosis: 10-year outcomes of the Regression of Myocardial Fibrosis After Aortic Valve Replacement study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceObservational
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12 authors.
Funding
Abstract
backgroundIn aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve replacement (AVR), left ventricular hypertrophy regression occurs, but early cellular and extracellular dynamics are unknown.
methodsPatients with severe symptomatic aortic stenosis undergoing surgical or transcatheter AVR were prospectively recruited. Pre- and early post-AVR cardiac magnetic resonance imaging assessed left ventricular remodeling, global longitudinal strain, and T1 mapping to determine extracellular volume fraction and volume of cellular and extracellular compartments.
resultsIn all, 39 patients (aged 71.4±9.8 years, male 79%, aortic valve peak velocity 4.4±0.5 m/s) underwent cardiac magnetic resonance before and at median 7.7 weeks post-AVR. Left ventricular mass index reduced significantly by 15.4% (
conclusionsWithin 8 weeks of AVR for aortic stenosis, substantial left ventricular hypertrophy regression occurs involving both cellular and extracellular compartments, demonstrating the early myocardial adaptability to afterload relief. Cellular compartment regression is greater than extracellular regression, leading to an apparent increase in extracellular volume fraction. Mode of intervention did not affect degree of reverse remodeling, indicating that both are effective at resulting beneficial changes post-AVR. REGISTRATION: URL: https://www.isrctn.com; Unique identifier: NCT04627987.
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