Evidence map›Paper›PMID 39629263›Full record

ReviewFrontiers in aging2024

Mesenchymal stem cells and their exosomes mitigate osteoarthritis by restoring the balance between proinflammatory Teffs and Tregs.

Tianhao Liu, Chunxiao Ran, Dewei Zhao, Fan Yang, Qiang Guo, Jiahui Yang, Xiuzhi Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Stem Cells in Aging and Anti-Aging.Stem cell reviews and reports · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianhao Liu *Zhongshan Clinical College, Dalian University, Dalian, Liaoning, China.
Chunxiao Ran *Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Dewei ZhaoZhongshan Clinical College, Dalian University, Dalian, Liaoning, China.
Fan YangDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Qiang GuoZhongshan Clinical College, Dalian University, Dalian, Liaoning, China.
Jiahui YangDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Xiuzhi ZhangDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a degenerative joint disease caused by chronic inflammation that damages articular cartilage. In addition to the wear and tear of joints, aberrant remodelling driven by a significant presence of inflammatory mediators within the joint is one of the key mechanisms in the pathogenesis of OA. Among these factors, hyperactivation of Teffs subsets plays a crucial role in promoting this pathological process. The immune imbalance between proinflammatory CD4

Indexed as

effector T cellimmunomodulatorymesenchymal stem cellosteoarthritisregulatory T cell

Identifiers

PMID39629263
PMCPMC11611854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.