ArticleEngineering microbiology2023
Fungal arginine-containing cyclodipeptide synthases are finally revealed.
Article in Engineering microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Biosynthetic pathways without any identifiable core enzymes may encode unknown (biosynthetic route)-unknown (molecular structure) natural products. However, bioinformatics-guided mining for such unknown-unknown metabolites is challenging. Recently, an unknown-unknown biosynthetic route has been deciphered in fungi. It was found that a class of enzymes previously annotated as hypothetical proteins catalyze the biosynthesis of arginine-containing cyclodipeptides (CDPs). This advances the understanding of the biosynthesis of CDPs and highlights the vast potential of unknown-unknown natural products encoded by microbial genomes.
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