ReviewEngineering microbiology2022
Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes.
Review in Engineering microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mining Actinomycetes' Metabolomes and Genomes for Anti-Phytophthora infestans Compounds.Microbial biotechnology · 2025Article
- A highly efficient heterologous expression platform to facilitate the production of microbial natural products in Streptomyces.Microbial cell factories · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse family of polycyclic polyphenols. Some of them are consequently suggested as lead structures for drug development. Among them, rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannulated [5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin unit. This type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities, including antimicrobial, anticancer, and enzyme inhibition activity. The unique structures, intriguing biosynthesis, and marked bioactivities of rubromycins have drawn considerable attention from several chemists and biologists. This review covers the isolation, characterization, biosynthesis, and biological studies of these structurally diverse and complex rubromycins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.