Evidence map›Paper›PMID 39628955›Full record

ArticleAdvances in radiation oncology2025

Cone Beam Computed Tomography-Based Online Adaptive Radiation Therapy of Esophageal Cancer: First Clinical Experience and Dosimetric Benefits.

Nicolas Bachmann, Daniel Schmidhalter, Frédéric Corminboeuf, Martin D Berger, Yves Borbély, Ekin Ermiş, Emanuel Stutz, Binaya K Shrestha, Daniel M Aebersold, Peter Manser and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Adaptive radiotherapy for gastrointestinal malignancies.Radiation oncology (London, England) · 2025
    Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicolas BachmannDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Daniel SchmidhalterDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Frédéric CorminboeufDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Martin D BergerDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Yves BorbélyDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Ekin ErmişDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Emanuel StutzDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Binaya K ShresthaDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Daniel M AebersoldDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Peter ManserDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.
Hossein HemmatazadDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern Switzerland, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Radiation therapy (RT) plays a key role in the management of esophageal cancer (EC). However, toxicities caused by proximity of organs at risk (OAR) and daily target coverage caused by interfractional anatomic changes are of concern. Daily online adaptive RT (oART) addresses these concerns and has the potential to increase OAR sparing and improve target coverage. We present the first clinical experience and dosimetric investigations of cone beam CT-based oART in EC using the ETHOS platform. Methods and Materials: Treatment fractions of the first 10 EC patients undergoing cone beam CT-based oART at our institution were retrospectively analyzed. The prescription dose was 50.4 Gy in 28 fractions. The same clinical target volume (CTV) and planning target volume (PTV) margins as for nonadaptive treatments were used. For all sessions, the timestamp of each oART workflow step, PTV size, target volume doses, mean heart dose, and lung V Results: Following automatic propagation, the CTV was adapted by the physician in 164 (59%) fractions. The adapted treatment plan was selected in 276 (99%) sessions. The median time needed for an oART session was 28 minutes (range, 14.8-43.3). Compared to the scheduled plans, a significant relative reduction of 9.5% in mean heart dose (absolute, 1.6 Gy; Conclusions: Although being resource-intensive, oART for EC is feasible in a reasonable timeframe and results in increased OAR sparing and improved target coverage, even without a reduction of margins. Further studies are planned to evaluate the potential clinical benefits.

Identifiers

PMID39628955
PMCPMC11612653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.