Evidence map›Paper›PMID 39628840›Full record

ArticleAdvanced functional materials2024

Oxidized mRNA Lipid Nanoparticles for

Alvin J Mukalel, Alex G Hamilton, Margaret M Billingsley, Jacqueline Li, Ajay S Thatte, Xuexiang Han, Hannah C Safford, Marshall S Padilla, Tyler Papp, Hamideh Parhiz and 2 more

Abstract read
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Nanomaterials Drive In Vivo CAR Immune Cells Engineering.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  3. Review
  4. Review
  5. The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.Drug delivery and translational research · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. CAR-macrophages: a new chapter in cancer immunotherapy.Acta biochimica et biophysica Sinica · 2026
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Natural carrier systems in cancer vaccines and immunotherapy.Human vaccines & immunotherapeutics · 2025
    Review
  17. Review
  18. In vivo CAR cell therapy: from bench to bedside.Journal of hematology & oncology · 2025
    Review
  19. In vivo CAR engineering for immunotherapy.Nature reviews. Immunology · 2025
    Review
  20. CAR-Macrophage Cell Therapy: A New Era of Hope for Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alvin J MukalelDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Alex G HamiltonDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Margaret M BillingsleyDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Jacqueline LiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Ajay S ThatteDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Xuexiang HanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Hannah C SaffordDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Marshall S PadillaDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Tyler PappDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Hamideh ParhizDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Drew WeissmanDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Funding

A data-driven drug delivery (4D) platform for probing and treating the chemoresistant bone marrow microenvironmentDP2TR002776 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL, MICHAEL J · 2018 to 2018
$2.4M
NCATS NIH HHS DP2 TR002776
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) monocyte and macrophage therapies are promising solid tumor immunotherapies that can overcome the challenges facing conventional CAR T cell therapy. mRNA lipid nanoparticles (mRNA-LNPs) offer a viable platform for

Identifiers

PMID39628840
PMCPMC11611297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.