Evidence map›Paper›PMID 39628834›Full record

ArticleIntegrated pharmacy research & practice2024

Antibiotic Dispensing Practices Among Community Retail Pharmacies and Registered Drugstores: Results from a Simulated Client Study in Lilongwe, Malawi.

Adriano Focus Lubanga, Akim Nelson Bwanali, Watipaso Kamanga, Bernard Sindani Kathewera, Tumaini John Makole, Samuel L Mpinganjira, Steward Mudenda, Collins Mitambo, Yechan Cho, Daniel Yeum and 3 more

Abstract read
In one paragraph

Article in Integrated pharmacy research & practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adriano Focus LubangaClinical Research Education and Management Services (CREAMS), Lilongwe, Malawi.ORCID 0000-0002-5491-5412
Akim Nelson BwanaliClinical Research Education and Management Services (CREAMS), Lilongwe, Malawi.ORCID 0009-0005-2070-0041
Watipaso KamangaClinical Research Education and Management Services (CREAMS), Lilongwe, Malawi.
Bernard Sindani KatheweraDepartment of Pharmacy, Queen Elizabeth Central Hospital, Blantyre, Malawi.ORCID 0009-0000-0367-4551
Tumaini John MakolePharmacist, Pharmacy Council of Tanzania, Dar Es Salaam, Tanzania.ORCID 0009-0007-7258-4403
Samuel L MpinganjiraSchool of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.ORCID 0000-0002-2034-7701
Steward MudendaDepartment of Pharmacy, School of Health Sciences, University of Zambia, Lusaka, Zambia.ORCID 0000-0003-1692-8981
Collins MitamboAntimicrobial Resistance National Coordination Centre, Public Health Institute of Malawi, Lilongwe, Malawi.
Yechan ChoYouth with Talents, Fairfax, VA, 22030, USA.ORCID 0009-0001-5427-6120
Daniel YeumYouth with Talents, Fairfax, VA, 22030, USA.
Jonathan Sukhee ChungStem Research Institute, Inc, Fairfax, VA, 22030, USA.
Jooheon ParkEuropean and Developing Countries Clinical Trials Partnership (EDCTP), Strategic Partnerships and Capacity Development- Head of Africa Office, Cape Town, Republic of South Africa.
Thomas NyirendaClinical Research Education and Management Services (CREAMS), Lilongwe, Malawi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Antimicrobial resistance (AMR) is largely driven by the inappropriate use of antibiotics. This has been attributed to the non-prescription sale of antibiotics in retail drug outlets. Despite the rising number of retail drug outlets in Malawi, the practice of drug dispensing in private pharmacies has not been evaluated. This study therefore assessed the prevalence of non-prescription sales of antibiotics in retail drug outlets in Lilongwe, Malawi. Methods: A community-based simulated client cross-sectional study was conducted in Lilongwe, Malawi from December 2023 to February 2024 using mystery shopping. Data were analyzed using IBM SPSS software version 29 using both descriptive and Analytical statistics. We computed simple proportions and conducted a hypotheses test using Chi-Square to test for Significance. Results: Antibiotic dispensing practices were surveyed in 51 retail drug outlets comprising 36 retail pharmacies and 15 drugstores. 35.3% (n=18) of the drug outlets had drug dispensing done by pharmacists, 13.7% (n=7) by pharmacy technicians, 21.5% (n=11) by pharmacy assistants and 25.5% (n=15) by drug dispensers who had no pharmacy-related training. The rate of non-prescription sales of antibiotics ranged between 53% for acute diarrhoea and 92% for upper respiratory tract infections. Amoxicillin was the most dispensed antibiotic across all case scenarios. Over 50% of dispensed antibiotics were done upon recommendation of the drug dispensers in the absence of a doctor's prescription. Furthermore, for all the dispensed antibiotics across all case scenarios, no advice was given for finishing a full course of the antibiotics. Conclusion: This study found high rates of over-the-counter dispensing of antibiotics, which call for urgent and comprehensive regulatory measures to control antibiotic consumption in an urban part of Malawi that risks increased AMR. These could range from enacting stringent antibiotic dispensing policies to deploying digital systems to monitor prescription practices and community education on rational antibiotic use.

Indexed as

Antimicrobial resistancedrug outletsdrug storesnon-prescription salesover-the-counter dispensingpharmacies

Identifiers

PMID39628834
PMCPMC11611745

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.