ArticleiScience2024
The first interneuron of the mouse visual system is tailored to the natural environment through morphology and electrical coupling.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.bioRxiv : the preprint server for biology · 2026Article
- A comprehensive study of c-Kit-expressing amacrine cells in the mammalian retina.Scientific reports · 2025Article
- Morphology and connectivity of retinal horizontal cells in two avian species.Frontiers in cellular neuroscience · 2025Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The topographic complexity of the mouse retina has long been underestimated. However, functional gradients exist, which reflect the non-uniform statistics of the visual environment. Horizontal cells are the first visual interneurons that shape the receptive fields of down-stream neurons. We asked whether regional specializations are present in terms of horizontal cell density distributions, morphological properties, localization of gap junction proteins, and the spatial extent of electrical coupling. These key features were asymmetrically organized along the dorsoventral axis. Dorsal cells were less densely distributed, had larger dendritic trees, and electrical coupling was more extensive than in ventral cells. The steepest change occurred at the visual horizon. Our results show that the cellular and synaptic organization of the mouse visual system are adapted to the visual environment at the earliest possible level and that horizontal cells are suited to form the substrate for the global gradient of ganglion cell receptive fields.
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