Evidence map›Paper›PMID 39628307›Full record

ArticleFuture medicinal chemistry2026

Synthesis, DFT, ADMET and molecular docking studies of thiazole derived thiazolidinone-based chalcone derivatives: alzheimer's disease current therapies.

Muhammad Shahid Nadeem, Jalaluddin Azam Khan, Imran Kazmi, Ehssan Moglad, Muhammad Afzal, Sami I Alzarea, Fazal Rahim, Shoaib Khan, Khushi Muhammad, Gaurav Gupta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Shahid NadeemDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Jalaluddin Azam KhanDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Imran KazmiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Ehssan MogladDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.
Muhammad AfzalDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, Jeddah, Saudi Arabia.
Sami I AlzareaDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Fazal RahimDepartment of Chemistry, Hazara University, Mansehra, Pakistan.
Shoaib KhanDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, Pakistan.
Khushi MuhammadDepartment of Bioteechnology and Genetic Engineeringh, Hazara University, Mansehra, Pakistan.
Gaurav GuptaDepartment of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical, Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimNitrogen and sulfur-containing compounds are the core components utilized for synthesis of different heterocyclic moieties. METHODS &

resultsIn this research, a series of new analogues containing thiazolidinone have been synthesized

conclusionAnalog

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsMolecular Docking SimulationThiazolesThiazolidinesAcetylcholinesteraseButyrylcholinesteraseDensity Functional TheoryHumansMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsThiazolesThiazolidinesAChEBuChESynthesisthiazolethiazolidinone & chalcone

Identifiers

PMID39628307
PMCPMC12987514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.