Evidence map›Paper›PMID 39627953›Full record

ArticleMagnetic resonance in medicine2025

Mechanically anisotropic phantoms for magnetic resonance elastography.

Kevin N Eckstein, Daniel Yoon, Margrethe Ruding, Ramin Balouchzadeh, Aaliyah Thompson-Mazzeo, Ruth J Okamoto, Curtis L Johnson, Matthew D J McGarry, Philip V Bayly

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. 3D rotational shear wave elasticity imaging (3D-RSWEI) in anisotropic lattice phantoms.Journal of the mechanical behavior of biomedical materials · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kevin N EcksteinMechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-4626-5322
Daniel YoonMechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-3924-6409
Margrethe RudingMechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA.
Ramin BalouchzadehMechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA.
Aaliyah Thompson-MazzeoMechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA.
Ruth J OkamotoMechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA.
Curtis L JohnsonBiomedical Engineering, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0002-7760-131X
Matthew D J McGarryThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Philip V BaylyMechanical Engineering and Materials Science, Washington University, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0003-4303-0704

Funding

High-Resolution, Anisotropic MR Elastography of the BrainR01EB027577 · NIBIB · UNIVERSITY OF DELAWARE · PI BAYLY, PHILIP V, JOHNSON, CURTIS L · 2019 to 2022
$2.7M
TRAINING IN REGENERATIVE MEDICINET32EB028092 · NIBIB · WASHINGTON UNIVERSITY · PI Farshid Guilak · 2020 to 2026
$2.0M
Replacement of a 4.7-T Small-Animal MRI Scanner with a 9.4-T SystemS10OD026913 · OD · WASHINGTON UNIVERSITY · PI ACKERMAN, JOSEPH J. H. · 2019 to 2019
$2.0M
NIBIB NIH HHS R01 EB027577NIBIB NIH HHS T32 EB028092NIH HHS R01 EB027577NIH HHS S10 OD026913NIH HHS S10OD026913Office of Naval Research N00014-22-1-2198Office of Naval Research N00014-24-1-2599
6 · The paper itself

Abstract

purposeImaging phantoms with known anisotropic mechanical properties are needed to evaluate magnetic resonance elastography (MRE) methods to estimate anisotropic parameters. The aims of this study were to fabricate mechanically anisotropic MRE phantoms, characterize their mechanical behavior by direct testing, then assess the accuracy of MRE estimates of anisotropic properties using a transversely isotropic nonlinear inversion (TI-NLI) algorithm.

methodsDirectionally scaled and unscaled lattices were designed to exhibit anisotropic or isotropic mechanical properties. Lattices were three-dimensionally printed in poly(ethelyne glycol) diacrylate using a commercial digital light processing printer, then infilled with gelatin to form a composite material. Benchtop testing determined two shear stiffnesses,

resultsIn benchtop tests, geometrically scaled lattice composites exhibited the following anisotropic properties:

conclusionAnisotropic MRE phantoms are created by embedding anisotropic three-dimensionally printed lattices into a softer matrix. The TI-NLI algorithm accurately estimates spatial contrast in anisotropic properties.

Indexed as

Elasticity Imaging TechniquesMagnetic Resonance ImagingPhantoms, ImagingAlgorithmsAnisotropyElastic ModulusEquipment DesignReproducibility of Results3D‐printed latticesanisotropyimaging phantomsmagnetic resonance elastography

Identifiers

PMID39627953
PMCPMC11893262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.