ArticleArchives of public health = Archives belges de sante publique2024
The impact of single and multiple occurrences, as well as the sequence of occurrences, of primary gastrointestinal cancer on overall survival: a comprehensive analysis based on the surveillance, epidemiology, and end results database in the United States from 2016 to 2019.
Article in Archives of public health = Archives belges de sante publique, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
introductionGastrointestinal cancers encompass malignant tumors of multiple digestive system organs in humans. Each type of digestive system cancer also contains different histological types, each of which has a distinct prognosis. The survival time of cancer patients has significantly extended with the development of modern medicine, allowing for primary cancers occurring more than once in a lifetime.
methodsThe study analyzed multiple primary gastrointestinal cancers, including esophagus, stomach, liver, gallbladder, small bowel, colon, rectum, and anus, based on the Surveillance, Epidemiology, and End Results (SEER) database from 2016 to 2019 in the United States. A total of 119,760 cases were included in this study. Each gastrointestinal cancer was analyzed separately based on the International Classification of Diseases for Oncology third edition (ICD-O-3) for the common histologic type. Meanwhile, based on the sequence of cancer occurrence in the patients, they were divided into the one primary (OP) group and the multiple primaries (MP) group. The multiple primaries group was further subdivided into the first of multiple primaries (FMP) group and the non-first of multiple primaries (NFMP) group. The Kaplan-Meier method with the log-rank test was used to analyze overall survival (OS), while the Cox regression model was used for univariate and multivariate analyses.
resultsThe study enrolled nine organs of the digestive system and twenty histologic types of primary gastrointestinal cancers. The characteristics of patients in different groups with various cancers, overall survival of these patients, and the risk factors for developing these cancers were comprehensively analyzed. The comprehensive analysis revealed the connection between the occurrence sequence of cancers and different outcomes for patients.
conclusionsDifferent prognoses were observed in patients with different sequences of various primary gastrointestinal cancers. Patients with high mortality cancers in the FMP group may have potential factors, such as high treatment sensitivity, that could lead to improved OS. Patients with low mortality cancers in the NFMP group could benefit from positive treatment therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.