Evidence map›Paper›PMID 39627705›Full record

ArticleBMC cancer2024

FTO-mediated demethylation of MTUS1/ATIP1 promotes tumor progression in head and neck squamous cell carcinoma.

Dongxiao Tang, Congyuan Cao, Wuguo Li, Anxun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dongxiao Tang *Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China.
Congyuan Cao *Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China.
Wuguo LiAnimal Experiment Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China.
Anxun WangDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China. wanganx@mail.sysu.edu.cn.

Funding

National Natural Science Foundation of China 82173041
6 · The paper itself

Abstract

backgroundHead and neck squamous cell carcinoma (HNSCC) has been recognized as the seventh most prevalent malignant tumor globally. It is a malignant neoplasm that arises from the mucosal epithelium of head and neck region. In our previous research, we have demonstrated that MTUS1/ATIP1 exhibits anti-cancer properties in HNSCC. Nevertheless, the underlying mechanism responsible for the reduction of MTUS1/ATIP1 expression has not been investigated.

methodsHNSCC and adjacent normal tissues were collected and examined using m

resultsFTO was observed to be markedly upregulated and showed a negative correlation with MTUS1/ATIP1 expression in HNSCC. FTO was responsible for mediating m

conclusionsOur research elucidated the functional importance of FTO-mediated m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorCell ProliferationDemethylationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceTumor Suppressor ProteinsAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanMTUS1 protein, humanTumor Suppressor ProteinsDemethylationFTOHead and neck squamous cell carcinomaMTUS1/ATIP1N6-methyladenosine

Identifiers

PMID39627705
PMCPMC11613461

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.