Evidence map›Paper›PMID 39627484›Full record

ArticleJournal of molecular histology2024

Exposure to a 0.9-GHz electromagnetic field on postnatal days 21-45 may trigger the renin-angiotensin system in male rat: a histological and biochemical study.

Ayşe İkinci Keleş, Haydar Kaya, Gökhan Keleş, Hüseyin Serkan Erol, Tolga Mercantepe, Ersan Odaci

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayşe İkinci KeleşDepartment of Histology and Embryology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye. ayse_ikinci@hotmail.com.ORCID http://orcid.org/0000-0003-0716-5695
Haydar KayaDepartment of Electrical and Electronics, Faculty of Engineering, Karadeniz Technical University, Trabzon, Türkiye.ORCID http://orcid.org/0000-0003-3060-000X
Gökhan KeleşHe works freelance outside of university, Aksaray, Türkiye.ORCID http://orcid.org/0000-0002-4875-9820
Hüseyin Serkan ErolDepartment of Biochemistry, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu, Türkiye.ORCID http://orcid.org/0000-0002-9121-536X
Tolga MercantepeDepartment of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Türkiye.ORCID http://orcid.org/0000-0002-8506-1755
Ersan OdaciDepartment of Histology and Embryology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye.ORCID http://orcid.org/0000-0002-4644-477X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to examine the relationship between the renin-angiotensin system (RAS) and histological and biochemical changes occurring in the kidney tissue of male rats exposed to a 0.9 GHz electromagnetic field (EMF). Twelve male rats aged 21 days were randomly assigned to control (C-Gr) and EMF (EMF-Gr) groups. No procedure was performed on C-Gr, while the EMF-Gr rats were exposed to a 0.9 GHz EMF on postnatal days 21-45 (one hour a day for 25 days). Tissues were removed at the end of the experiment and evaluated using biochemical, and histopathological methods. Increased kidney tissue volume and weight and total body weight were determined in the group exposed to EMF. Lipid peroxidation, glutathione, catalase, and superoxide dismutase also increased in the kidney tissue of the EMF-Gr rats. Histopathological evaluation revealed cortical/medullary bleeding/obstruction and widespread fibrosis, dilatation, vacuolization, and degeneration in distal and proximal tubules, decreased and atypical parietal cells, and degeneration in epithelial cells. Additionally, dilated and degenerated glomeruli in the Malpighian body, Bowman's membrane degeneration and degeneration in the vascular pole, podocyte, pedicel and mesangial cells were also observed. As a result of exposure to EMF, oxidative stress, tissue volume and weight increased, and histopathological changes caused the formation of a pathway that triggers RAS in kidney tissues. In conclusion, long-term exposure to 0.9 GHz EMF can activate the renin-angiotensin system in the rat kidney, and we think that such activation may be associated with structural, histopathological, and biochemical changes occurring in renal tissue.

Indexed as

Electromagnetic FieldsKidneyOxidative StressRenin-Angiotensin SystemAnimalsBody WeightCatalaseGlutathioneLipid PeroxidationMaleRatsSuperoxide DismutaseCatalaseGlutathioneSuperoxide DismutaseElectromagnetic fieldKidneyMale ratOxidative stressRenin-angiotensin system

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.