Evidence map›Paper›PMID 39627483›Full record

ArticleScientific reports2024

Retrograde evoked compound action potentials as an alternative for close-loop spinal cord stimulation.

Nianshuang Wu, Zhen Wu, Cheng Zhang, Changzhe Wu, Xiaolin Huo, Jinzhu Bai, Guanghao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nianshuang WuBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Zhen WuBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Cheng ZhangBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Changzhe WuBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Xiaolin HuoBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Jinzhu BaiDepartment of Spine and Spinal Cord Surgery, Beijing Bo'ai Hospital, Rehabilitation Research Center, Beijing, China.
Guanghao ZhangBeijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, 100190, China. zhangguanghao@mail.iee.ac.cn.ORCID 0000-0002-6445-2271

Funding

National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 51977205National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 52077209
6 · The paper itself

Abstract

Evoked compound action potential (ECAP) is an important parameter in close-loop spinal cord stimulation (SCS). The recording electrode is typically positioned proximal to the stimulation electrode to capture the antegrade ECAP signals generated by ascending fibers. However, relatively little research has been conducted on retrograde ECAPs. This study investigated retrograde ECAPs using custom-made epidural electrodes in 11 adult male Sprague-Dawley rats. Results show that the average motor threshold (MT) and ECAP threshold (ECAPT) for 11 anesthetized rats were 218.18 ± 69.54 μA and 107.27 ± 27.96 μA, respectively. The ECAP amplitudes increased with increasement of the stimulation current and pulse width (PW), and were larger in awake rats than in anesthetized rats. Additionally, aside from ECAPs recorded by a commercial electrophysiological recorder, ECAPs were also recorded by a custom-made amplifier for the purpose of future long-term implantation, but the custom-made amplifier showed lower signal to noise ratio than the commercial amplifier. In conclusion, this study illustrates that retrograde ECAP may also be considered as a feedback signal for close-loop SCS and more sophisticated ECAP recording circuits are needed to form a close-loop system.

Indexed as

Action PotentialsRats, Sprague-DawleySpinal CordSpinal Cord StimulationAnimalsMaleRatsClose-loopEvoked compound action potentialMotor thresholdSpinal cord stimulation

Identifiers

PMID39627483
PMCPMC11615308

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.