Evidence map›Paper›PMID 39627473›Full record

ArticleParasitology research2024

The cyclophilin D (CypD) of Toxoplasma gondii is involved in the parasite's response to oxidative stress damage.

Zhu Ying, Yihan Wu, Zhepeng Sun, Jing Liu, Qun Liu

Abstract read
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Article in Parasitology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhu Ying *National Key Laboratory of Veterinary Public Health and Safety, China Agricultural University, Beijing, 100193, China.
Yihan Wu *National Key Laboratory of Veterinary Public Health and Safety, China Agricultural University, Beijing, 100193, China.
Zhepeng SunNational Key Laboratory of Veterinary Public Health and Safety, China Agricultural University, Beijing, 100193, China.
Jing LiuNational Key Laboratory of Veterinary Public Health and Safety, China Agricultural University, Beijing, 100193, China. liujingvet@cau.edu.cn.
Qun LiuNational Key Laboratory of Veterinary Public Health and Safety, China Agricultural University, Beijing, 100193, China. qunliu@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mitochondrial permeability transition pore (mPTP) significantly impacts mitochondrial responses to cell death signals through its structural opening. Cyclophilin D (CypD) serves as a key regulator of the mPTP and plays a pivotal role in governing mitochondrial responses to cell death. In this study, we have demonstrated that Toxoplasma expresses a homolog of cyclophilin D, named TgCypD, which is localized in the mitochondria. Depletion of TgCypD resulted in a modest inhibition of tachyzoite invasion and proliferation, with no notable effect on mitochondrial morphology. However, TgCypD deficiency led to the inhibition of cytochrome c release from mitochondria into the cytosol, thereby imparting resistance to oxidative stress-induced cell death. Our findings suggest that T. gondii contains the mPTP component protein TgCypD, which is intricately involved in regulating mitochondrial responses to cell death.

Indexed as

CyclophilinsMitochondriaOxidative StressToxoplasmaAnimalsCell DeathCytochromes cMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePeptidyl-Prolyl Isomerase FProtozoan ProteinsCyclophilinsCytochromes cMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePeptidyl-Prolyl Isomerase FProtozoan ProteinsCyclophilin DMitochondrial permeability transition pore (mPTP)Oxidative stress damage responseToxoplasma gondii

Identifiers

PMID39627473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.