Evidence map›Paper›PMID 39627409›Full record

ArticleScientific reports2024

Pre-pregnancy obesity is associated with an altered maternal metabolome and reduced Flt3L expression in preterm birth.

Ismail Sebina, Charles Bidgood, Felicity Stalley, Gunter Hartel, Terra Stark, Leonie Callaway, Akwasi Amoako, Christoph Lehner, Marloes Dekker Nitert, Simon Phipps

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ismail SebinaInfection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia. i.sebina@uq.edu.au.
Charles BidgoodSchool of Biomedical Sciences, Queensland University of Technology, Brisbane, 4000, QLD, Australia.
Felicity StalleyWomen's and Newborn Services, Royal Brisbane and Women's Hospital, Herston, QLD, 4006, Australia.
Gunter HartelStatistics Unit, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.
Terra StarkMetabolomics Australia (Queensland Node), The University of Queensland, Brisbane, QLD, 4072, Australia.
Leonie CallawayFaculty of Medicine, The University of Queensland, Brisbane, QLD, 4072, Australia.
Akwasi AmoakoFaculty of Medicine, The University of Queensland, Brisbane, QLD, 4072, Australia.
Christoph LehnerFaculty of Medicine, The University of Queensland, Brisbane, QLD, 4072, Australia.
Marloes Dekker NitertSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
Simon PhippsInfection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.

Funding

National Health and Medical Research Council 1141581National Health and Medical Research Council 569693QIMR Berghofer Medical Research Institute 2021 Seeding award to Ismail Sebina
6 · The paper itself

Abstract

Mechanisms linking pre-pregnancy obesity to increased preterm birth risk are unclear. Here, we examined the impact of pre-pregnancy obesity on metabolites, Fms-related tyrosine kinase 3 ligand (Flt3L), and proinflammatory cytokine profiles in preterm birth. We used cytokine bead array, ELISA and Gas Chromatography-Mass Spectrometry (GC-MS) to determine cytokine and metabolite profiles in maternal and cord blood samples from 124 pregnant women in Australia, who gave birth at term (n = 86) or preterm (n = 38). Besides the expected variations in birth weight and gestational age, all demographic characteristics, including pre-pregnancy body mass index, were similar between the term and preterm birth groups. Mothers in the preterm birth group had reduced Flt3L (P = 0.002) and elevated IL-6 (P = 0.002) compared with term birthing mothers. Among mothers who gave birth preterm, those with pre-pregnancy obesity had lower Flt3L levels (P = 0.02) compared with lean mothers. Flt3L and IL-6 were similar in cord blood across both groups, but TNFα levels (P = 0.02) were reduced in preterm newborns. Metabolomic analysis revealed significant shifts in essential metabolites in women with pre-pregnancy obesity, some of which were linked to preterm births. Our findings suggest that maternal pre-pregnancy obesity alters the metabolome and reduces Flt3L expression, potentially increasing risk of preterm birth.

Indexed as

Membrane ProteinsMetabolomeObesityPremature BirthAdultBody Mass IndexCytokinesFemaleFetal BloodHumansInfant, NewbornInterleukin-6PregnancyCytokinesflt3 ligand proteinInterleukin-6Membrane Proteins

Identifiers

PMID39627409
PMCPMC11615298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.