Evidence map›Paper›PMID 39627400›Full record

ArticleEndocrine2025

Better cardiometabolic/inflammatory profile is associated with differences in the supraclavicular adipose tissue activity of individuals with T2DM.

Ivan Luiz Padilha Bonfante, Higor da Silva Segantim, Kauê Neto Soares Mendonça, Murilo Augusto Belmiro de Oliveira, Milena Monfort-Pires, Renata Garbellini Duft, Keryma Chaves da Silva Mateus, Mara Patricia Traina Chacon-Mikahil, Celso Darío Ramos, Licio Augusto Velloso and 1 more

Abstract read
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Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ivan Luiz Padilha BonfanteLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil. ivanlpb@unicamp.br.
Higor da Silva Segantim *Higher Interdisciplinary Training Program (PROFIS), University of Campinas, Campinas, SP, Brazil.
Kauê Neto Soares Mendonça *Higher Interdisciplinary Training Program (PROFIS), University of Campinas, Campinas, SP, Brazil.
Murilo Augusto Belmiro de Oliveira *Higher Interdisciplinary Training Program (PROFIS), University of Campinas, Campinas, SP, Brazil.
Milena Monfort-PiresLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
Renata Garbellini DuftLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil.
Keryma Chaves da Silva MateusLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil.
Mara Patricia Traina Chacon-MikahilLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil.
Celso Darío RamosDepartment of Radiology, University of Campinas, Campinas, SP, Brazil.
Licio Augusto VellosoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
Cláudia Regina CavaglieriLaboratory of Exercise Physiology, School of Physical Education, University of Campinas, Campinas, SP, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303571/2018-7Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/08751-3
6 · The paper itself

Abstract

purposeBrown adipose tissue (BAT), located in the supraclavicular region, has been associated with a better cardiometabolic profile and reduced risk of developing non-communicable chronic diseases (NCD), in addition to being associated with a healthier phenotype in obesity. However, it is unknown whether greater supraclavicular adipose tissue activity could be associated with a healthier metabolic profile in people already diagnosed with type 2 diabetes (T2DM). Thus, the present work evaluated if supraclavicular adipose tissue activity is associated with metabolic and molecular markers in individuals with T2DM.

methodsBased on a cluster study, individuals with T2DM were divided into groups according to high or low-standard uptake value (SUV) evaluated in the supraclavicular adipose tissue area by [18F]-fluorodeoxyglucose and positron emission tomography-computed tomography (

resultsWhen we evaluated the whole sample, women showed higher SUV, which favored a difference between groups in sex-related markers. On the other hand, volunteers in the high-SUV group showed lower BMI, monocytes count, triglycerides/glucose index (TYG-index) and z score of metabolic syndrome (MS) values, as well as lower triglycerides, and VLDL concentrations. Moreover, they also had enhanced expression of thermogenic genes in subcutaneous fat. When analyzing only women, the differences in markers associated with sex disappear, and a lower count of leukocytes, platelets, along with lower TYG-index, z score of MS values, and triglycerides, VLDL, LDL, and TNFα concentrations were observed in women with the high SUV. In addition, higher expression of thermogenic genes and BECN1 were detected.

conclusionHigher supraclavicular adipose tissue SUV in individuals with T2DM is associated with a better cardiometabolic/inflammatory profile and expression of thermogenic genes. CLINICAL

trial registrationUTN: U1111-1202-1476 - 08/20/2020.

Indexed as

Adipose Tissue, BrownDiabetes Mellitus, Type 2InflammationAdultAgedFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron Emission Tomography Computed TomographyFluorodeoxyglucose F18Beige adipose tissueBrown adipose tissueMetabolismOverweightThermogenesisType 2 diabetes

Identifiers

PMID39627400

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.