Evidence map›Paper›PMID 39627379›Full record

ArticleNPJ precision oncology2024

Assessing CD36 and CD47 expression levels in solid tumor indications to stratify patients for VT1021 treatment.

Suming Wang, Victor Zota, Melanie Y Vincent, Donna Clossey, Jian Jenny Chen, Michael Cieslewicz, Randolph S Watnick, James Mahoney, Jing Watnick

Abstract read
In one paragraph

Article in NPJ precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suming WangVigeo Therapeutics, Cambridge, MA, USA. Suming.Wang@vigeotx.com.
Victor ZotaVigeo Therapeutics, Cambridge, MA, USA.
Melanie Y VincentVigeo Therapeutics, Cambridge, MA, USA.
Donna ClosseyVigeo Therapeutics, Cambridge, MA, USA.
Jian Jenny ChenVigeo Therapeutics, Cambridge, MA, USA.
Michael CieslewiczVigeo Therapeutics, Cambridge, MA, USA.
Randolph S WatnickBoston Children's Hospital, Boston, MA, USA.
James MahoneyVigeo Therapeutics, Cambridge, MA, USA.
Jing WatnickVigeo Therapeutics, Cambridge, MA, USA. Jing.Watnick@vigeotx.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the development of cancer biomarkers and targeted therapies, most cancer patients do not have a specific biomarker directly associated with effective treatment options. We have developed VT1021 that induces the expression of thrombospondin-1 (TSP-1) in myeloid-derived suppressor cells (MDSCs) recruited to the tumor microenvironment (TME). Our studies identified CD36 and CD47 as dual biomarkers that can be used as patient stratifying tools and prognostic biomarkers for VT1021 treatment.

Identifiers

PMID39627379
PMCPMC11614903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.