ArticleScientific reports2024
Memory reactivation generates new, adaptive behaviours that reach beyond direct experience.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Wakeful targeted memory reactivation during short rest periods modulates early motor learning.NPJ science of learning · 2026Article
- Awake reactivation is not a uniform process.Trends in cognitive sciences · 2025Article
- Episodic Memories Bias Contextual Threat Inferences after Aerobic and Mind-Body Exercise.Mental health and physical activity · 2025Article
- Memory reactivation during rest forms shortcuts in a cognitive map.Scientific reports · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Periods of rest and sleep help us find hidden solutions to new problems and infer unobserved relationships between discrete events. However, the mechanisms that formulate these new, adaptive behavioural strategies remain unclear. One possibility is that memory reactivation during periods of rest and sleep has the capacity to generate new knowledge that extends beyond direct experience. Here, we test this hypothesis using a pre-registered study design that includes a rich behavioural paradigm in humans. We use contextual Targeted Memory Reactivation (TMR) to causally manipulate memory reactivation during awake rest. We demonstrate that TMR during rest enhances performance on associative memory tests, with improved discovery of new, non-directly trained associations, and no change observed for directly trained associations. Our findings suggest that memory reactivation during awake rest plays a critical role in extracting new, unobserved associations to support adaptive behavioural strategies such as inference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.