ArticleNature communications2024
Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years.
Registry-linked trialAbstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07685457 (A Prospective Clinical Study to Evaluate the Safety and Efficacy of Virus Specific T-Cell Administration in Pediatric Patients With Systemic Viral Infection Following Allogeneic Hematopoietic Stem Cell Transplantation.), which is not on this map. Cited by 16 papers.
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0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Clinical Study to Evaluate the Safety and Efficacy of Virus Specific T-Cell Administration in Pediatric Patients With Systemic Viral Infection Following Allogeneic Hematopoietic Stem Cell Transplantation.
Who cites it
16 citing papers in PubMed.
- Article
- Adoptive T-cell therapies in the clinic.Bioengineering & translational medicine · 2026Review
- Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR-T Cell Recipients-PART 2: Antiviral Therapy and Virus-Specific T Cell Therapy for HCMV in Allo-HSCT.Reviews in medical virology · 2026Review
- Smooth Muscle Disruptive Feature Defines Molecular Subtyping, Risk Stratification, and Metastatic Potential in Prostate Cancer.Annals of surgical oncology · 2026Article
- A multidimensional workflow profiling of allogeneic virus-specific T cell therapies reveals potency-linked signatures.Nature communications · 2026Article
- "Innovative diagnostics and treatments of infections in transplantation," report from the 2025Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Hospital exemption use of virus-specific T-lymphocytes in children: early experience within the Allovista clinical trial framework.Frontiers in immunology · 2026Article
- General Commentary: From hospital exemption to evidence: a statistical framework for leveraging real-world data.Frontiers in immunology · 2026Article
- Human leukocyte antigen genotype modulates cytomegalovirus- and Epstein-Barr virus-specific T-cell response in healthy donors for optimized virus-specific T-cell donor selection.Frontiers in immunology · 2026Article
- Adoptive T-cell therapy for virus-associated diseases.Clinical microbiology reviews · 2025Review
- Harnessing virus-specific T cells: expanding therapeutic strategies across diverse populations.Blood advances · 2025Review
- Modulating CD226 and PD-(L)1 pathways improves CMV-specific CD8＋T cell responses in the absence of IL-2.BMB reports · 2025Article
- Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy.Molecular therapy. Methods & clinical development · 2025Article
- Can Adoptive Immunotherapy With Hepatitis E Virus (HEV)-Specific T Cells Address the Unmet Need in Refractory Chronic HEV Infection?Open forum infectious diseases · 2025Article
- "Attack!" Cellular Therapies to Attack Pathogens and Tumors.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025Article
- Allogeneic 'off-the-shelf' SARS-CoV-2-specific adoptive T-cell therapy for refractory viral infection and end organ disease.Clinical & translational immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
75 authors.
Michelle A NellerQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
George R AmbalathingalQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.ORCID 0000-0002-4270-4423
Nada HamadDepartment of Haematology, St Vincent's Hospital, School of Clinical Medicine, University of New South Wales and School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.
Joe SasadeuszDepartment of Haematology, St Vincent's Hospital, School of Clinical Medicine, University of New South Wales and School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.
Rebecca PearsonDepartment of Haematology, St Vincent's Hospital, School of Clinical Medicine, University of New South Wales and School of Medicine, University of Notre Dame, Sydney, New South Wales, Australia.
Chien-Li Holmes-LiewRoyal Adelaide Hospital, Adelaide, South Australia, Australia.
Deepak SinghalRoyal Adelaide Hospital, Adelaide, South Australia, Australia.
Matthew TunbridgeRoyal Adelaide Hospital, Adelaide, South Australia, Australia.
Wei Yang NgRoyal Adelaide Hospital, Adelaide, South Australia, Australia.
Kirsty SharplinRoyal Adelaide Hospital, Adelaide, South Australia, Australia.
Andrew MooreQueensland Children's Hospital, South Brisbane, Queensland, Australia.ORCID 0000-0001-8062-1779
David DeambrosisQueensland Children's Hospital, South Brisbane, Queensland, Australia.
Trisha Soosay-RajQueensland Children's Hospital, South Brisbane, Queensland, Australia.ORCID 0000-0001-6935-0402
Peter McNaughtonQueensland Children's Hospital, South Brisbane, Queensland, Australia.ORCID 0000-0002-4600-8839
Morag WhyteQueensland Children's Hospital, South Brisbane, Queensland, Australia.
Chris FraserQueensland Children's Hospital, South Brisbane, Queensland, Australia.
Andrew GriggAustin Hospital, Heidelberg, Victoria, Australia.
David KlimanRoyal North Shore Hospital, St Leonards, New South Wales, Australia.ORCID 0000-0002-2020-0275
Ashish BajelPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Katherine CumminsPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-9041-0828
Mark DowlingPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Zhi Han YeohPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Simon J HarrisonPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-4555-6582
Amit KhotPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Sarah TanPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Izanne RoosPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-0371-3666
Ray Mun KooPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Sara DohrmannPeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
David RitchiePeter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Brynn WainsteinSydney Children's Hospital, Randwick, New South Wales, Australia.ORCID 0000-0001-5704-650X
Karen McClearySydney Children's Hospital, Randwick, New South Wales, Australia.
Adam NelsonSydney Children's Hospital, Randwick, New South Wales, Australia.
Bradley GardinerThe Alfred Hospital, Melbourne, Victoria, Australia.
Shafqat InamThe Alfred Hospital, Melbourne, Victoria, Australia.
Xavier BadouxSt George Public Hospital, Kogarah, New South Wales, Australia.
Kris MaWestmead Hospital, Westmead, New South Wales, Australia.
Claudia ToroRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Diane HannaRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.
David HughesRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Rachel ConyersRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Theresa ColeRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Shiqi Stacie WangRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Lynette CheeRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-4250-4448
Jacqueline FlemingRoyal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Ashley IrishFiona Stanley Hospital, Murdoch, Western Australia, Australia.ORCID 0000-0002-9577-3764
Duncan PurtillFiona Stanley Hospital, Murdoch, Western Australia, Australia.ORCID 0000-0002-0408-8455
Julian CooneyFiona Stanley Hospital, Murdoch, Western Australia, Australia.
Peter ShawThe Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Siok-Keen TeyQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Stewart HuntRoyal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Elango Subramonia PillaiRoyal Brisbane and Women's Hospital, Herston, Queensland, Australia.
George JohnRoyal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Michelle NgPerth Children's Hospital, Nedlands, Western Australia, Australia.
Shanti RamachandranPerth Children's Hospital, Nedlands, Western Australia, Australia.
Peter HopkinsThe Prince Charles Hospital, Chermside, Queensland, Australia.
Daniel ChambersThe Prince Charles Hospital, Chermside, Queensland, Australia.
Scott CampbellPrincess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Ross FrancisPrincess Alexandra Hospital, Woolloongabba, Queensland, Australia.ORCID 0000-0002-3995-7040
Nicole IsbelPrincess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Paula MarltonPrincess Alexandra Hospital, Woolloongabba, Queensland, Australia.ORCID 0000-0003-2512-917X
Hilary ReddiexQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Katherine K MatthewsQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.ORCID 0000-0002-4402-451X
Meggie VoogtQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Archana PanikkarQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Leone BeagleyQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Sweera RehanQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Shannon BestQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Jyothy RajuQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Laetitia Le TexierQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Pauline CrooksQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Matthew SolomonQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Lea LekieffreQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Sriganesh SrihariQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Corey SmithQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.ORCID 0000-0002-7550-9595
Rajiv KhannaQueensland Immunology Research Centre, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Rajiv.Khanna@qimrberghofer.edu.au.ORCID 0000-0003-2241-0353
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with "off-the-shelf" allogeneic T cells directed to a combination of Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration's Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder. Adoptive immunotherapy is well tolerated with few adverse effects. Importantly, 46/71 (65%) patients show definitive clinical improvement including reduction in viral load, clinical symptoms and complete resolution of end-organ disease. In addition, seven high-risk patients remain disease free. Based on this long-term encouraging clinical experience, we propose that a dedicated nationally funded centre for anti-viral cellular therapies should be considered to provide T cell therapies for critically ill patients for compassionate use.
Indexed as
Immunotherapy, AdoptiveT-LymphocytesAdolescentAdultAgedAustraliaBK VirusCompassionate Use TrialsFemaleHerpesvirus 4, HumanHumansImmunocompromised HostMaleMiddle AgedNew ZealandRetrospective Studies
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Registered trials
NCT07685457ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.