Evidence map›Paper›PMID 39626965›Full record

ArticleLife science alliance2025

Eliza S Lee, Harrison W Smith, Yifan E Wang, Sean Sj Ihn, Leticia Scalize de Oliveira, Nevraj S Kejiou, Yijing L Liang, Syed Nabeel-Shah, Robert Y Jomphe, Shuye Pu and 2 more

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eliza S LeeDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Harrison W SmithDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Yifan E WangDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Sean Sj IhnDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Leticia Scalize de OliveiraDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Nevraj S KejiouDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Yijing L LiangCentre for Computational Medicine, Hospital for Sick Children, Toronto, Canada.
Syed Nabeel-ShahDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Robert Y JompheDepartment of Biochemistry, University of Toronto, Toronto, Canada.ORCID 0000-0002-0244-6968
Shuye PuTerrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Canada.
Jack F GreenblattDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.ORCID 0000-0003-1762-2861
Alexander F PalazzoDepartment of Biochemistry, University of Toronto, Toronto, Canada alex.palazzo@utoronto.ca.ORCID 0000-0002-9700-1995

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans, misprocessed mRNAs containing intact 5' Splice Site (5'SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a component of the U1 snRNP. In

Indexed as

AdenosineCell NucleusRNA, MessengerRNA Splice SitesHeLa CellsHumansNerve Tissue ProteinsRNA-Binding ProteinsRNA SplicingRNA Splicing FactorsRNA StabilityAdenosineNerve Tissue ProteinsN-methyladenosineRNA-Binding ProteinsRNA, MessengerRNA Splice SitesRNA Splicing FactorsYTHDC1 protein, human

Identifiers

PMID39626965
PMCPMC11629677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.