Evidence map›Paper›PMID 39626860›Full record

ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2025

Phenotypic and genotypic correlates of the sodium bicarbonate-responsive phenotype among methicillin-resistant Staphylococcus aureus isolates from skin and soft-tissue infections.

Selvi C Ersoy, Sabrina L Madrigal, Liang Chen, Jose Mediavilla, Barry Kreiswirth, Evelyn A Flores, Loren G Miller, Yan Q Xiong, Ewan M Harrison, Beth Blane and 5 more

Abstract read
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In one paragraph

Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. An Achilles' heel for methicillin-resistantAntimicrobial agents and chemotherapy · 2026
    Review
  2. Infection and immunity · 2025
    Review
  3. Review
  4. Sensitizing methicillin-resistantAntimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Selvi C ErsoyThe Lundquist Institute for Biomedical Innovations, Division of Infectious Disease, Harbor-UCLA Medical Center, Torrance, CA, USA; David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA. Electronic address: selvi.ersoy@lundquist.org.
Sabrina L MadrigalCalifornia State University-Los Angeles, Department of Biological Sciences, Los Angeles, CA, USA.
Liang ChenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Jose MediavillaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Barry KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Evelyn A FloresThe Lundquist Institute for Biomedical Innovations, Division of Infectious Disease, Harbor-UCLA Medical Center, Torrance, CA, USA.
Loren G MillerThe Lundquist Institute for Biomedical Innovations, Division of Infectious Disease, Harbor-UCLA Medical Center, Torrance, CA, USA; David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Yan Q XiongThe Lundquist Institute for Biomedical Innovations, Division of Infectious Disease, Harbor-UCLA Medical Center, Torrance, CA, USA; David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Ewan M HarrisonWellcome Sanger Institute, Hinxton, United Kingdom; Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Beth BlaneDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Sharon J PeacockWellcome Sanger Institute, Hinxton, United Kingdom; Department of Medicine, University of Cambridge, Cambridge, United Kingdom; London School of Hygiene and Tropical Medicine, London, United Kingdom.
Robin PatelDepartment of Microbiology, Mayo Clinic, Rochester, MN, USA.
Henry F ChambersSchool of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Arnold S BayerThe Lundquist Institute for Biomedical Innovations, Division of Infectious Disease, Harbor-UCLA Medical Center, Torrance, CA, USA; David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Richard A ProctorDepartments of Medicine and Medical Microbiology/Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Funding

Bicarbonate-Mediated Enhancement of Beta-Lactam-MRSA Killing: Mechanisms and Clinical TranslatabilityR01AI146078 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI146078Wellcome Trust
6 · The paper itself

Abstract

objectivesThe objective of this study is to assess the frequency of the novel sodium bicarbonate (NaHCO

methodsAntimicrobial susceptibility testing was performed to determine susceptibility phenotypes. Targeted and whole-genome sequencing with a genome-wide sequence analysis were conducted to identify specific and novel genotypes of interest that may be associated with the NaHCO

resultsThe NaHCO DISCUSSION: NaHCO

Indexed as

Anti-Bacterial AgentsMethicillin-Resistant Staphylococcus aureusSodium BicarbonateSoft Tissue InfectionsStaphylococcal Skin InfectionsGenotypeHumansMicrobial Sensitivity TestsPhenotypeUnited StatesWhole Genome SequencingAnti-Bacterial AgentsSodium BicarbonateMethicillin-resistant Staphylococcus aureus (MRSA)NaHCO(3)-ResponsivesabRSkin and soft-tissue infection (SSTI)Sodium bicarbonate (NaHCO(3))β-lactams

Identifiers

PMID39626860
PMCPMC11913587

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.