ArticleThe Journal of urology2025
Prevalence, Incidence, and Age at Diagnosis of Boys With Hypospadias: A Nationwide Population-Based Epidemiological Study.
Article in The Journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effect of autologous platelet-rich treatment in hypospadias repair: a systematic review and meta-analysis.Pediatric surgery international · 2026Pooled it
- Association between anogenital distance and hypospadias: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Anatomic factors associated with postoperative events and reintervention after secondary urethroplasty in children with urethral strictures after hypospadias repair.World journal of urology · 2026Article
- Effects of platelet-rich fibrin on the biological properties of rabbit adipose-derived stem cells in vitro.Journal of molecular histology · 2026Article
- Selective use of grafted TIP urethroplasty in distal to proximal penile hypospadias: a single-center cohort study.World journal of urology · 2026Article
- Recurrent Constellations of Embryonic Malformations (RCEM): Teratogenicity Linked to Transient Hypoxia and Hormone Pregnancy Tests Agrees With RCEM and Suggest a Reactive Oxygen Species Pathogenesis.Birth defects research · 2026Review
- Prenatal Low Testosterone Levels Induced byBiomedicines · 2025Article
- Review: Hormone Pregnancy Tests Were Teratogenic by the Same Failed Abortion and Hypoxia-Related Mechanism as Misoprostol.Birth defects research · 2025Review
- Pyramid urethral mobilisation hypospadias repair for distal variant: experience with 70 cases.Frontiers in pediatrics · 2025Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to assess the diagnostic prevalence, incidence, diagnostic age, and surgical volume of hypospadias in Denmark. MATERIALS AND
methodsMales with a hypospadias diagnosis in the Danish National Patient Registry (n = 10,276) were identified (1977-2019). A diagnostic algorithm, validated by medical file review (n = 1710), confirmed diagnoses and severity (distal/proximal). The yearly prevalence (live-born hypospadias boys/100,000 newborn boys) and incidence (first hypospadias registration in the Danish National Patient Registry/100,000 boys in background population) were calculated. Age at diagnosis and number of health care contacts were calculated. Poisson regression was used to analyze temporal trends.
resultsHypospadias was verified in 9189 males (89.4%; distal 8404 [91.5%]; proximal 785 [8.5%]). From 1977 to 2006, the prevalence rose significantly to a mean of 503 (95% CI: 440-565) and peaked at 847 (distal 768, proximal 79) in 2007. From 2008 to 2018, the prevalence stabilized (mean 774, 95% CI: 738-810). A significant rise in incidence was observed. Age at diagnosis decreased from 1977 to 2019. Proximal hypospadias was diagnosed earlier (median 0 years, IQR, 0-0.5) than distal (median 0.2 years, IQR, 0-1.9) and had more (
conclusionsSince 1977, the prevalence of diagnosed hypospadias cases significantly increased and peaked around 800 per 100,000 live boys in 2007. The diagnostic age decreased, proximal cases were diagnosed earlier, and there were more surgical admissions than distal cases. A significant proportion were never operated.
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