Evidence map›Paper›PMID 39626666›Full record

ArticleCurrent biology : CB2024

Doublecortin reinforces microtubules to promote growth cone advance in soft environments.

Alessandro Dema, Rabab A Charafeddine, Jeffrey van Haren, Shima Rahgozar, Giulia Viola, Kyle A Jacobs, Matthew L Kutys, Torsten Wittmann

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Structural switching of tubulin in the microtubule lattice.Biochemical Society transactions · 2025
    Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alessandro DemaDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Rabab A CharafeddineDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Jeffrey van HarenDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Shima RahgozarDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Giulia ViolaDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Kyle A JacobsDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Matthew L KutysDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Torsten WittmannDepartment of Cell & Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: torsten.wittmann@ucsf.edu.

Funding

Probing Microtubule Function in Neuronal DevelopmentR01NS107480 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2018 to 2022
$2.0M
Decoding cortical Notch signaling and morphogenic instruction at cell-cell interfacesR35GM150987 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KUTYS, MATTHEW L · 2023 to 2025
$1.3M
Wide-field super-resolution spinning disk confocal microscopeS10OD028611 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2020 to 2020
$600k
Spinning disk confocal / FRAP microscope for quantitative live cell imagingS10RR026758 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026758NIGMS NIH HHS R35 GM150987NIH HHS S10 OD028611NINDS NIH HHS R01 NS107480
6 · The paper itself

Abstract

Doublecortin (DCX) is a microtubule (MT)-associated protein in immature neurons. DCX is essential for early brain development,

Indexed as

Doublecortin Domain ProteinsDoublecortin ProteinGrowth ConesMicrotubule-Associated ProteinsMicrotubulesNeuropeptidesHumansInduced Pluripotent Stem CellsNeurogenesisNeuronsDCX protein, humanDoublecortin Domain ProteinsDoublecortin ProteinMicrotubule-Associated ProteinsNeuropeptidesbiomechanicscytoskeletondoublecortingenome editinggrowth conehuman-induced pluripotent stem cellslissencephalymicrotubuleneuron morphogenesistraction force microscopy

Identifiers

PMID39626666
PMCPMC11740832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.