Evidence map›Paper›PMID 39626338›Full record

ReviewHearing research2025

Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography.

Elizabeth S Olson, Wei Dong, Brian E Applegate, Karolina K Charaziak, James B Dewey, Brian L Frost, Sebastiaan W F Meenderink, Jong-Hoon Nam, John S Oghalai, Sunil Puria and 3 more

Abstract readReview
In one paragraph

Review in Hearing research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Longitudinal Vibrations in the Organ of Corti are Limited to Its Core.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elizabeth S OlsonDepartment of Otolaryngology - Head and Neck Surgery, Department of Biomedical Engineering, Columbia University, New York City, NY USA. Electronic address: eao2004@columbia.edu.
Wei DongVA Loma Linda Healthcare System, Loma Linda, CA, USA, Department of Otolaryngology - Head and Neck Surgery, Loma Linda University Health, Loma Linda, CA USA.
Brian E ApplegateCaruso Department of Otolaryngology -Head and Neck Surgery, Department of Ophthalmology, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA USA.
Karolina K CharaziakCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA USA.
James B DeweyCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA USA.
Brian L FrostThe Rockefeller University, New York City, NY USA.
Sebastiaan W F MeenderinkVA Loma Linda Healthcare System, Loma Linda, CA, USA.
Jong-Hoon NamDepartment of Mechanical Engineering, University of Rochester, Rochester, NY USA.
John S OghalaiCaruso Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Los Angeles, CA USA.
Sunil PuriaMassachusetts Eye and Ear, Harvard Medical School, Boston, MA USA.
Tianying RenDepartment of Otolaryngology - Head and Neck Surgery, Oregon Health and Science University, Portland, OR USA.
C Elliott StrimbuDepartment of Otolaryngology - Head and Neck Surgery, Columbia University, New York City, NY USA.
Marcel van der HeijdenDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands.

Funding

Three-dimensional and Multiscale Organ of Corti BiomechanicsR01DC007910 · NIDCD · STANFORD UNIVERSITY · PI Sunil Puria · 2007 to 2026
$9.4M
Cochlear mechanics in the mouseR01DC014450 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John S Oghalai · 2015 to 2026
$5.6M
Diversity Supplement to Auditory Mechanics and Cochlear AmplificationR01DC015362 · NIDCD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ELIZABETH S. OLSON · 2016 to 2026
$5.6M
The Role of the Organ of Corti for Cochlear Power TransmissionR01DC014685 · NIDCD · UNIVERSITY OF ROCHESTER · PI Jong-Hoon Nam · 2015 to 2026
$4.1M
Mechanisms of cochlear synaptopathy after noise or blast traumaR01DC017741 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OGHALAI, JOHN S · 2020 to 2024
$3.1M
Mass transport in the inner-ear fluidR01DC020150 · NIDCD · UNIVERSITY OF ROCHESTER · PI Jong-Hoon Nam · 2023 to 2026
$2.0M
Cochlear micromechanical mechanisms underlying psychoacoustic phenomenaR01DC021143 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI TIANYING REN · 2023 to 2026
$1.9M
Mechanisms of amplification and nonlinearity in the mouse cochleaR01DC021006 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI James Braden Dewey · 2024 to 2026
$1.2M
Understanding the dynamics of cochlear amplificationR00DC016906 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHARAZIAK, KAROLINA · 2022 to 2024
$744k
Role of Organ of Corti Outer Hair Cell/Vibration Hot Spots in Distortion Product Otoacoustic Emission GenerationR21DC019998 · NIDCD · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI DONG, WEI · 2022 to 2022
$403k
Reconstruction of three-dimensional organ of Corti micromechanical motion patterns via optical coherence tomographyF31DC020621 · NIDCD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI FROST, BRIAN LANCE · 2022 to 2023
$79k
NIDCD NIH HHS F31 DC020621NIDCD NIH HHS R00 DC016906NIDCD NIH HHS R01 DC007910NIDCD NIH HHS R01 DC014450NIDCD NIH HHS R01 DC014685NIDCD NIH HHS R01 DC015362NIDCD NIH HHS R01 DC017741NIDCD NIH HHS R01 DC020150NIDCD NIH HHS R01 DC021006NIDCD NIH HHS R01 DC021143NIDCD NIH HHS R21 DC019998RRD VA I01 RX003491
6 · The paper itself

Abstract

Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a vibrometer for hearing research. The application of OCT in this field, particularly for studying cochlear mechanics, represents a revolutionary advance over previous technologies. OCT provides detailed evidence of the motions of components within the organ of Corti, extending beyond the first-encountered surface of observation. By imaging through the bony capsule as well as through the round window membrane, OCT has measured vibration at multiple locations along the cochlear spiral, in vivo, under nearly natural conditions. In this document, we present examples of recent research findings to illustrate the applications of OCT in studying cochlear mechanics in both normal and impaired ears.

Indexed as

CochleaOrgan of CortiTomography, Optical CoherenceVibrationAnimalsBiomechanical PhenomenaHearingHumansMotion

Identifiers

PMID39626338
PMCPMC11671289

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.