Evidence map›Paper›PMID 39626021›Full record

ArticleThe international journal of neuropsychopharmacology2024

Oxytocin Reduces Methylphenidate-Induced Dorsal Striatal Dopamine Release in Male Rhesus Macaques.

Mary R Lee, Ehsan Shokri Kojori, William Dieckmann, Erick Singley, Julie A Mattison, Peter Herscovitch, Lorenzo Leggio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mary R LeePsychiatric Neuromodulation Service, Veterans Affairs Medical Center, Washington, District of Columbia, USA.ORCID 0000-0002-2235-0816
Ehsan Shokri KojoriNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
William DieckmannPositron Emission Tomography Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Erick SingleyNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Julie A MattisonTranslational Gerontology Branch, National Institute on Aging, NIH Animal Center, Dickerson, Maryland, USA.
Peter HerscovitchPositron Emission Tomography Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
Lorenzo LeggioDepartment of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA.

Funding

Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIAAA000218 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LEGGIO, LORENZO · 2013 to 2020
$22.8M
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIADA000635 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LEGGIO, LORENZO · 2020 to 2025
$15.2M
Division of Intramural Clinical and Biological ResearchIntramural NIH HHS ZIA AA000218Intramural NIH HHS ZIA DA000635Intramural Research ProgramNIAAA NIH HHSNIA NIH HHSNIDA NIH HHSNIH HHS ZIA-DA000635Office of Behavioral and Social Sciences Research
6 · The paper itself

Abstract

backgroundOxytocin is being evaluated as a potential treatment for psychostimulant use disorders. It is unknown what effect oxytocin has on dopamine signaling in response to psychostimulants in brain regions such as the striatum where oxytocin and dopamine interact to process natural rewards. We investigated the effect of oxytocin on striatal dopamine release stimulated by methylphenidate whose mechanism of action is analogous to that of cocaine.

methodsWe conducted an [11C] raclopride positron emission tomography study to assess striatal dopamine release in male rhesus macaques treated with oxytocin (80 IU) (administered via the intranasal [N = 5] and intravenous [N = 6] routes) followed by methylphenidate/[11C] raclopride.

resultsOxytocin delivered by both routes significantly reduced methylphenidate-stimulated dopamine release in the dorsal striatum (caudate/putamen). These effects were, in part, evidenced by a reduction in dorsal striatal [11C] raclopride binding potential (increased dopamine release) following oxytocin administration.

conclusionsThe results provide translational and mechanistic evidence for the potential role of oxytocin as a treatment for psychostimulant use disorders.

Indexed as

Administration, IntranasalCorpus StriatumDopamineMacaca mulattaMethylphenidateOxytocinPositron-Emission TomographyRacloprideAnimalsCentral Nervous System StimulantsDopamine Uptake InhibitorsMaleCentral Nervous System StimulantsDopamineDopamine Uptake InhibitorsMethylphenidateOxytocinRaclopridedopamineintranasalmethylphenidateoxytocinraclopride

Identifiers

PMID39626021
PMCPMC11681423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.