Evidence map›Paper›PMID 39625962›Full record

ArticlePloS one2024

Treatment outcomes and associated factors in severe malaria patients at University of Gondar Hospital, Northwest Ethiopia: A retrospective study (2020-2023).

Marshet Anteneh, Mezgebu Silamsaw Asres, Geberehiwot Lema Legese, Meron Asmamaw Alemayehu, Dagmawi Woldesenbet, Desalew Getahun Ayalew

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In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marshet AntenehBahir-Dar Blood Bank, Amhara National Regional State Health Bureau, Bahir-Dar, Ethiopia.
Mezgebu Silamsaw AsresDepartment of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Geberehiwot Lema LegeseDepartment of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.ORCID 0000-0002-1665-9526
Meron Asmamaw AlemayehuDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.ORCID 0000-0002-1852-0771
Dagmawi WoldesenbetDepartment of Medical Laboratory Science, College of Medicine and Health Science, Wachemo University, Hossana, Ethiopia.ORCID 0009-0006-1844-4365
Desalew Getahun AyalewDepartment of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria continues to be the most prevalent life-threatening parasitic illness in Ethiopia. Its clinical spectrum ranges from mild to severe, with a propensity for death. In Ethiopia, it accounts for 10% of hospital admission. Identifying predictors of malaria-related mortality is crucial for aiding high-risk patient identification and enabling timely intervention.

objectiveOur study aimed to assess treatment outcomes and factors associated with mortality among severe malaria patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

methodsA retrospective cross-sectional study examined 383 randomly chosen patients with severe malaria, spanning a four-year period leading up to the data collection date, encompassing July 2023 back to June 2020. Data were collected from the hospital records. A structured questionnaire was used to collect the data. EpiData version 3.1 and SPSS version 20 were used to clean and analyze the data, respectively. Logistic regression analysis was conducted to determine associations and reported by the odds ratio at p < 0.05 with 95% confidence intervals.

resultsAmong the 383 eligible patients, the majorities were males (56.66%) and resided in rural areas (66.32%). Over 84% of them were referred from health facilities. Plasmodium falciparum was the major parasite identified in 78% of cases. The magnitude of death among severe malaria patients was 10.97%. Impaired consciousness, convulsions, jaundice, parasitemia level >2, and creatinine level ≥3 were significantly associated with death, with adjusted odds ratios (AOR) of 3.4 (95% CI: 1.3-8.3), 2.7 (95% CI: 1.004-7.492), 3.2 (95% CI: 1.173-9.182), 3.7 (95% CI: 1.516-9.113), and 11.7 (95% CI: 4.756-29.239), respectively.

conclusionOur study revealed a significant number of malaria-related deaths, with predictors such as age, impaired consciousness, convulsions, jaundice, parasitemia level, and creatinine level identified. Hence, it is imperative to implement intense and timely interventions for patients exhibiting these clinical manifestations to prevent malaria-related fatalities.

Indexed as

MalariaAdolescentAdultAgedAntimalarialsChildChild, PreschoolCross-Sectional StudiesEthiopiaFemaleHospitals, UniversityHumansMalaria, FalciparumMaleMiddle AgedPlasmodium falciparumAntimalarials

Identifiers

PMID39625962
PMCPMC11614224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.