SynthesisPloS one2024
Effect of post-stroke cognitive impairment and dementia on stroke recurrence and functional outcomes: A systematic review and meta-analysis.
Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of transcranial direct current stimulation combined with cognitive rehabilitation on cognitive function and activities of daily living in patients with post-stroke cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Machine learning-based prediction of 3-6-month post-stroke cognitive impairment using acute-phase clinical data: a two-center retrospective prognostic modeling study.BMC medical informatics and decision making · 2026Article
- Impact of hyperbaric oxygen therapy on serum lipid profiles and cognitive recovery in patients with post-stroke cognitive impairment: a retrospective cohort study.American journal of translational research · 2026Article
- Blood pressure variability and the risk of post-stroke cognitive impairment following atrial fibrillation related acute ischemic stroke.Clinical hypertension · 2026Article
- Association between diastolic blood pressure and post-stroke cognitive impairment: a real-world retrospective cohort study.Annals of medicine · 2025Article
- Is cognitive reserve associated with cognitive function across stroke severity? A longitudinal study among Chinese stroke patients.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPost-stroke cognitive impairment (PSCI) and dementia may have a significant impact on stroke recurrence and long-term functional outcomes of patients.
aimTo investigate the potential link between PSCI and dementia, and stroke recurrence, mortality, and poor functional outcomes of stroke survivors.
methodsA systematic search across Medline, Google Scholar, and Science Direct databases was done for studies that evaluated the association of PSCI and dementia with long-term stroke outcomes. The results were expressed as pooled hazard ratios (HR) with 95% confidence intervals (CI), and heterogeneity was assessed using the I2 statistic and the Chi-square test. Subgroup analyses were performed based on the sample size, geographical location, follow-up, and type of dementia/cognitive impairment. Study quality was evaluated using the Newcastle Ottawa Scale (NOS).
resultsThe meta-analysis included thirteen studies. Of them, ten studies (n = 4036) reported a significant association between PSCI and stroke recurrence, with a pooled HR of 1.33 (95% CI: 1.14-1.55, I2 = 84.6%). Subgroup analysis revealed a statistically significant association between PSCI and stroke recurrence across various subrgoups. Four studies (n = 1944) demonstrated that patients with PSCI had a higher risk of poor functional outcome, with a pooled HR of 1.68 (95% CI: 1.16-2.05, I2 = 80.0%). However, the multivariate analysis did not detect a significant association between PSCI and stroke mortality, with a pooled HR of 1.50 (95% CI: 0.94-2.40, I2 = 45.9%).
conclusionsThe study showed that PSCI was associated with 33% increased stroke recurrence and 68% higher rate of poor functional outcome. Our findings underscore the adverse impact of PSCI on stroke recurrence and functional outcomes, emphasizing the importance of early detection and targeted interventions to mitigate the cognitive impairment burden in stroke survivors.
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