ArticlePloS one2024
Salt restriction induced hyponatremia in hypertensive patients in Rwanda: A case control study.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Review
- Hyponatremia in patients with arterial hypertension: pathophysiology and management.Archives of medical science : AMS · 2023Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSalt restriction is a fundamental principle in the non-pharmacological management of hypertension. The World Health Organization recommends a daily sodium intake of less than 2 g/day. In East African countries, particularly Rwanda, there is a known prevalence of low sodium intake, with a mean sodium intake of 1.6 g/day. However, despite this dietary habit, the national protocol for treating hypertension, as well as common clinical practice, often fail to account for the low salt intake in Rwandan communities. Hypertensive patients are still frequently advised to reduce their salt intake, and in some cases, they are instructed to eliminate salt entirely.
objectivesThis study was designed to determine the association between salt restriction and hyponatremia in hypertensive patients.
methodsA case-control study was conducted over a period of 6 months at two tertiary hospitals in Rwanda, with hyponatremia as the outcome variable and salt restriction as the exposure variable. Age, gender, and use of diuretics were matched between the case and control groups. Serum sodium concentrations were measured, and participants were then categorized into groups. Questionnaires were used for interviews.
results245 participants meeting the inclusion criteria were selected, with 110 (44.9%) classified as cases and 135 (55.1%) as controls. Among them, 159 (64.8%) participants were restricted from consuming salt, with 74 (46.5%) following a salt-free diet. The odds of developing hyponatremia were 9.90 (95% CI, p < 0.001) among salt-restricted participants.
conclusionThere is a strong association between salt restriction and hyponatremia in hypertensive patients on treatment in this study.
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