ArticleClinical cancer research : an official journal of the American Association for Cancer Research2025
Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions.
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Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10citing papers in PubMed, 1 pooled it
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic and predictive molecular biomarkers in brain tumors across the lifespan: an age-stratified consensus statement.Journal of neuro-oncology · 2025Pooled it
- TRK inhibitors in pediatric gliomas.Neuro-oncology advances · 2026Review
- Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.Neuro-oncology · 2025Review
- A Novel C19orf47-AKT2 Chimeric RNA Generated by Cis-Splicing of Adjacent Genes Is Associated With Glioblastoma Prognosis.Annals of clinical and translational neurology · 2025Article
- Diffuse leptomeningeal glioneuronal tumour: molecular diagnosis, evolution and treatment.Acta neuropathologica communications · 2025Article
- TRK Inhibitors in Adult and Pediatric High-Grade Gliomas: A Systematic Review and Individual Participant Data Meta-Analysis.Cancers · 2025Review
- Precision Medicine for Pediatric Glioma and NF1-Associated Tumors: The Role of Small Molecule Inhibitors.Current oncology (Toronto, Ont.) · 2025Review
- The Growth Modulation Index (GMI) as an Efficacy Outcome in Cancer Clinical Trials: A Scoping Review with Suggested Reporting Guidelines.Current oncology reports · 2025Article
- Targeted therapy in pediatric central nervous system tumors: a review from the National Pediatric Cancer Foundation.Frontiers in oncology · 2025Review
- Perineuronal net degradation in aggressive glioblastomas withNeuro-oncology advancesArticle
Corrections and comments
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Authors and funding
92 authors.
Audrey-Anne LamoureuxDepartment of Neurosciences, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0009-0008-3878-8995
Michael J FisherDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0003-3408-3839
Lauriane LemelleSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Institut Curie, Paris, France.ORCID 0000-0002-3333-5048
Elke PfaffDivision of Pediatric Glioma Research, Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-3967-2264
Pouneh Amir-YazdaniDepartment of Neurosciences, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0000-0001-8403-7131
Christof KrammDivision of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-5017-926X
Bram De WildeGhent University Hospital, Ghent, Belgium.ORCID 0000-0003-0213-1322
Bernarda KazanowskaDepartment of Pediatric Hematology/Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland.
Caroline HutterDepartment of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2059-4814
Stefan M PfisterDivision of Pediatric Glioma Research, Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-5447-5322
Dominik SturmDivision of Pediatric Glioma Research, Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0003-0250-1696
David T W JonesDivision of Pediatric Glioma Research, Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-2036-5141
Daniel OrbachSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Institut Curie, Paris, France.ORCID 0000-0002-2520-139X
Gaëlle PierronSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Institut Curie, Paris, France.ORCID 0000-0002-2536-7680
Scott RaskinDepartment of Pediatrics, University of Cincinnati Medical School, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0003-1160-9842
Alexander DrilonMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.ORCID 0000-0001-6806-9061
Eli L DiamondMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.ORCID 0000-0001-5456-5961
Guilherme HaradaMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.ORCID 0000-0003-4012-3251
Michal ZapotockyDepartment of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.ORCID 0000-0002-9013-2546
Josef ZamecnikDepartment of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.ORCID 0000-0001-8697-9632
Lenka KrskovaDepartment of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.ORCID 0000-0002-6113-6310
Benjamin EllezamDepartment of Neurosciences, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0000-0002-8716-7924
Alexander G WeilDepartment of Neurosciences, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0000-0003-4162-6096
Dominic VenneDepartment of Neurosciences, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0000-0003-3978-3738
Marc BarritaultHospices Civils de Lyon, Lyon, France.ORCID 0000-0003-3311-4058
Pierre LeblondInstitut d'Hématologie et d'Oncologie Pédiatrique and Pluridisciplinar Research in Pediatric Oncology for Perspectives in Evaluation Care and Therapy (PROSPECT), Centre Leon Berard, Lyon, France.ORCID 0000-0002-7088-2614
Hallie ColtinDivision of Pediatric Hematology-Oncology, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0000-0003-0820-6276
Rawan HammadHospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-6293-7497
Uri TaboriHospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-5019-2683
Cynthia HawkinsHospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-2618-4402
Jordan R HansfordMichael Rice Centre for Hematology and Oncology, Adelaide, South Australia, Australia.ORCID 0000-0001-7733-383X
Deborah MeyranChildren's Cancer Centre, Royal Children's Hospital, Parkville, Victoria, Australia.ORCID 0000-0003-2723-8185
Craig ErkerIWK Health Centre, Halifax, Nova Scotia, Canada.ORCID 0000-0003-1394-7167
Kathryn McFaddenIWK Health Centre, Halifax, Nova Scotia, Canada.ORCID 0000-0002-7007-2267
Mariko SatoChildren's Hospital of Orange County, Orange, California.ORCID 0000-0002-4748-4634
Nicholas G GottardoDepartment of Pediatric Oncology and Hematology, Perth Children's Hospital, Perth, Western Australia, Australia.ORCID 0000-0002-1082-6776
Hetal DholariaDepartment of Pediatric Oncology and Hematology, Perth Children's Hospital, Perth, Western Australia, Australia.ORCID 0000-0003-1713-3822
Dorte Schou NørøxeDepartment of Oncology, DCCC-Brain Tumor Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-9921-8277
Hiroaki GotoKanagawa Children's Medical Center, Yokohama, Japan.ORCID 0000-0001-6737-1509
David S ZieglerChildren's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-7451-7916
Frank Y LinTexas Children's Hospital, Houston, Texas.ORCID 0000-0001-6738-844X
Donald Williams ParsonsTexas Children's Hospital, Houston, Texas.ORCID 0000-0002-8775-3501
Holly LindsayTexas Children's Hospital, Houston, Texas.ORCID 0000-0001-5654-841X
Tai-Tong WongTaipei Medical University, Taipei, Taiwan.ORCID 0000-0003-4075-6227
Yen-Lin LiuTaipei Medical University, Taipei, Taiwan.ORCID 0000-0002-7571-3123
Kuo-Sheng WuTaipei Medical University, Taipei, Taiwan.ORCID 0009-0001-1887-9768
Andrea T FransonUniversity of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-5361-7683
Eugene HwangChildren's National Hospital, Washington, District of Columbia.ORCID 0000-0002-3923-1135
Ana Aguilar-BonillaArnold Palmer Hospital, Orlando, Florida.ORCID 0000-0002-5327-449X
Sylvia ChengB.C. Children's Hospital, Vancouver, British Columbia, Canada.ORCID 0000-0002-4089-1739
Chantel CacciottiDivision of Hematology/Oncology, Department of Pediatrics, London Health Sciences Centre and Western University, London, Ontario, Canada.ORCID 0000-0002-4968-8956
Maura MassiminoFondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0002-5506-2001
Elisabetta SchiavelloFondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0002-8049-7445
Paul WoodMonash Children's Hospital, Clayton, Victoria, Australia.ORCID 0000-0003-1383-3450
Lindsey M HoffmanPhoenix Children's Hospital, Phoenix, Arizona.ORCID 0000-0002-8573-1747
Andréa CappellanoIOP-GRAACC/UNIFESP, Sao Paulo, Brasil.ORCID 0000-0002-3818-8876
Alvaro LassalettaHospital Infantil Universitario Niño Jesús, Madrid, Spain.ORCID 0000-0003-2881-1473
An Van DammeCliniques Universitaires Saint-Luc, Brussels, Belgium.ORCID 0000-0002-7114-201X
Anna LlortVall d'Hebron Children's Hospital, Barcelona, Spain.ORCID 0000-0001-9741-1655
Nicolas U GerberDepartment of Oncology, University Children's Hospital, Zurich, Switzerland.ORCID 0000-0002-1783-631X
Mariella Spalato CerusoInstitut Bergonié, Bordeaux, France.ORCID 0000-0002-7582-3365
Anne E BendelChildren's Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-2062-0974
Maggie SkrypekChildren's Minnesota, Minneapolis, Minnesota.ORCID 0009-0009-0158-9594
Dima HamidehAmerican University of Beirut Medical Center, Beirut, Lebanon.ORCID 0000-0003-2246-6621
Naureen MushtaqAga Khan University Hospital, Karachi, Pakistan.ORCID 0000-0002-5461-3350
Andrew WalterNemour Alfred I du Pont Hospital for Children, Wilmington, Delaware.ORCID 0000-0001-5653-5686
Nada JabadoMontreal Children's Hospital, Montréal, Quebec, Canada.ORCID 0000-0003-2485-3692
Aysha AlsahlawiMontreal Children's Hospital, Montréal, Quebec, Canada.ORCID 0009-0003-5157-5226
Jean-Pierre FarmerMontreal Children's Hospital, Montréal, Quebec, Canada.ORCID 0000-0003-2242-1984
Christina ColemanMontreal Children's Hospital, Montréal, Quebec, Canada.ORCID 0000-0001-5747-4045
Sabine MuellerUniversity of California, San Francisco, San Francisco, California.ORCID 0000-0002-3452-5150
Claire MazewskiChildren's Health Care of Atlanta, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0001-6970-0994
Dolly AguileraChildren's Health Care of Atlanta, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0001-9668-8177
Nathan J RobisonChildren's Hospital Los Angeles, Los Angeles, California.ORCID 0000-0001-8613-9772
Katrina O'HalloranChildren's Hospital Los Angeles, Los Angeles, California.ORCID 0000-0003-0573-0769
Samuel AbbouGustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.ORCID 0000-0002-7159-8869
Pablo BerlangaGustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-1110-7789
Birgit GeoergerGustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-4361-3643
Ingrid ØraLund University, Lund, Sweden.ORCID 0000-0002-3931-4125
Christopher L MoertelDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-5474-588X
Evangelia D RazisHygeia Hospital, Athens, Greece.ORCID 0000-0003-3873-2947
Anastasia VernadouHygeia Hospital, Athens, Greece.ORCID 0009-0005-1733-0625
François DucrayHospices Civils de Lyon, Lyon, France.ORCID 0000-0002-8150-5785
Charlotte BronnimannCHU Hôpital Saint André, Bordeaux, France.ORCID 0000-0002-2208-0545
Romuald SeizeurCHRU de Brest, Brest, France.ORCID 0000-0001-6519-9098
Matthew ClarkeThe Institute of Cancer Research, London, United Kingdom.ORCID 0000-0003-2405-5770
Adam C ResnickDivision of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0003-0436-4189
Mélanie AlvesDepartment of Neurosciences, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0009-0001-7243-3134
Chris JonesThe Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-8118-2296
François DozSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Institut Curie, Paris, France.ORCID 0000-0001-9286-4831
Theodore W LaetschDivision of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-8497-3138
Sébastien PerreaultDepartment of Neurosciences, University of Montreal, CHU Sainte-Justine, Montreal, Quebec, Canada.ORCID 0000-0002-4417-7698
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MIntegration of Imaging and Circulating Plasma Cell-Free DNA Sequencing Using MSK-ACCESS to Monitor Treatment Response and Predict Progression in Patients With Multiple Cancers on Targeted TherapyR01CA273224 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Michael F. Berger, Alexander Drilon · 2022 to 2026
$3.6MMolecular Pathogenesis and Therapy of Systemic Histiocytic NeoplasmsR37CA259260 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Eli Lous Diamond · 2021 to 2026
$3.3MNational Cancer Institute (NCI) 1R01CA251591001A1NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA273224NCI NIH HHS R37 CA259260
Abstract
purposeTropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients. EXPERIMENTAL
designWe conducted an international retrospective cohort study of patients with TRK fusion-driven central nervous system tumors.
resultsA total of 119 patients were identified. The median age at the time of diagnosis was 4.5 years. The majority were reported to have a histology consistent with a diagnosis of high-grade glioma (HGG; 57.1%) followed by low-grade glioma (LGG; 27.7%). Pediatric patients had a better prognosis, with a median overall survival of 185.5 months compared with 24.8 months in adults (P < 0.0001). Patients with LGG also had a better outcome when compared with HGG (P = 0.0012). The objective response was 68.8% with larotrectinib compared with 38.1% for nontargeted treatment.
conclusionsChildren with LGG had a favorable outcome compared with adult glioma and HGG. TRK inhibitors seem to improve tumor control.
Indexed as
Central Nervous System NeoplasmsGene FusionGliomaOncogene Proteins, FusionReceptor, trkAAdolescentAdultAgedChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedPrognosislarotrectinibOncogene Proteins, FusionProtein Kinase InhibitorsPyrazolesPyrimidinesReceptor, trkAReceptor, trkB
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