Evidence map›Paper›PMID 39625730›Full record

ArticleACS applied bio materials2024

Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay.

Sergiy Kyrylenko, Inna Chorna, Zhanna Klishchova, Ilya Yanko, Anton Roshchupkin, Volodymyr Deineka, Kateryna Diedkova, Anastasia Konieva, Oksana Petrichenko, Irina Kube-Golovin and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Sergiy KyrylenkoBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.ORCID 0000-0002-4343-0065
Inna ChornaBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.
Zhanna KlishchovaBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.
Ilya YankoBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.ORCID 0000-0001-6926-2461
Anton RoshchupkinBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.ORCID 0000-0003-3292-2862
Volodymyr DeinekaBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.
Kateryna DiedkovaBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.
Anastasia KonievaBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.
Oksana PetrichenkoUniversity of Latvia, Institute of Atomic Physics and Spectroscopy, 3 Jelgavas Street, Riga LV-1004, Latvia.
Irina Kube-GolovinDepartment of Anatomy, University Hospital, University Duisburg-Essen, Hufelandstr. 55, Essen D-45147, Germany.
Gunther WennemuthDepartment of Anatomy, University Hospital, University Duisburg-Essen, Hufelandstr. 55, Essen D-45147, Germany.
Emerson CoyNanoBioMedical Centre, Adam Mickiewicz University, 3, Wszechnicy Piastowskiej Str., Poznan 61-614, Poland.ORCID 0000-0002-4149-9720
Iryna RoslykMaterials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine.
Ivan BaginskiyMaterials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine.ORCID 0000-0002-0092-9018
Veronika ZahorodnaMaterials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine.ORCID 0000-0002-8873-015X
Oleksiy GogotsiMaterials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine.
Benjamin ChaconA.J. Drexel Nanomaterials Institute and Departmental of Materials Science and Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, United States.
Luciana P CartarozziLaboratory of Nerve Regeneration, Institute of Biology, University of Campinas, Campinas, São Paulo 13083-862, Brazil.
Alexandre L R OliveiraLaboratory of Nerve Regeneration, Institute of Biology, University of Campinas, Campinas, São Paulo 13083-862, Brazil.
Igor IatsunskyiNanoBioMedical Centre, Adam Mickiewicz University, 3, Wszechnicy Piastowskiej Str., Poznan 61-614, Poland.
Yury GogotsiA.J. Drexel Nanomaterials Institute and Departmental of Materials Science and Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-9423-4032
Maksym PogorielovBiomedical Research Center, Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.ORCID 0000-0001-9372-7791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MXenes are among the most diverse and prominent 2D materials. They are being explored in almost every field of science and technology, including biomedicine. In particular, they are being investigated for photothermal therapy, drug delivery, medical imaging, biosensing, tissue engineering, blood dialysis, and antibacterial coatings. Despite their proven biocompatibility and low cytotoxicity, their genotoxicity has not been addressed. To investigate whether MXenes interfere with DNA integrity in cultured cells, we loaded the cells with MXenes and examined the fragmentation of their chromosomal DNA by a DNA comet assay. The presence of both Ti

Indexed as

Biocompatible MaterialsComet AssayDNA DamageMaterials TestingAnimalsCell SurvivalDNAFibroblastsHumansMiceNiobiumParticle SizeTitaniumBiocompatible MaterialsDNANiobiumTitaniumcell deathcell viabilityDNA comet assayDNA fragmentationelectrophoresisMXeneNb4C3Txresazurin reduction assayTi3C2Tx

Identifiers

PMID39625730
PMCPMC12239077

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.