Evidence map›Paper›PMID 39625491›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Edaravone's reno-protective effects against chronic heat-stress exposure.

Laiali T Alquraan, Karem H Alzoubi, Sanaa Jaber, Omar F Khabour, Bahaa Al-Trad, Aseel Al-Shwaheen, Ghada Alomari, Suzie Y Rababa'h, Majed M Masadeh

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Laiali T AlquraanDepartment of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan.
Karem H AlzoubiDepartment of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, UAE. khalzoubi@just.edu.jo.
Sanaa JaberDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Omar F KhabourDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Bahaa Al-TradDepartment of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan.
Aseel Al-ShwaheenDepartment of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan.
Ghada AlomariDepartment of Biological Sciences, The Faculty of Science, Yarmouk University, Irbid, Jordan.
Suzie Y Rababa'hDepartment of Pharmacy, Faculty of Pharmacy, Jadara University, Irbid, Jordan.
Majed M MasadehDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Funding

Jordan University of Science and Technology 443/2022
6 · The paper itself

Abstract

Edaravone (EDV) is a potent antioxidant with anti-inflammatory properties. It is used to treat various diseases, especially neurodegenerative diseases. This study aims to examine EDV's potential renal protective effects on kidney injury induced by heat stress in rats. Male Wistar rats were segregated into four distinct groups (n = 16/group): control (Ctr), heat stress (HS), edaravone (EDV), and HS+EDV groups. Heat stress was applied 6 days a week for 30 min for 8 weeks, and EDV treatment (6 mg/kg. IP) was administered simultaneously in the HS+EDV group. After the experiment, blood and kidney tissue samples were gathered for subsequent analysis. Compared to the control group, the HS group exhibited a significant increase in serum creatinine and urea levels (P < 0.05). Additionally, malondialdehyde level and catalase activity, tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) mRNA expression were increased in the kidney tissue during HS. The renal tissues of the heat-stressed animal showed noticeable histological alterations compared to the control group. However, in the HS+EDV and EDV groups, the creatinine and urea concentrations in the blood were markedly reduced compared to the HS group (P < 0.05). In addition, renal oxidative stress biomarkers were normalized (malondialdehyde levels and catalase activity; P < 0.05). The histopathological alterations in the renal tissues of the groups treated with EDV were markedly diminished. In addition, the renal mRNA expression levels of IL-1β and TNF-α were markedly reduced in the HS+EDV group compared to the HS group (P < 0.05). EDV treatment in a heat-stress rat model demonstrated a protective effect on renal tissue, most likely due to its antioxidant and anti-inflammatory properties.

Indexed as

Anti-Inflammatory AgentsAntioxidantsAntipyrineEdaravoneHeat-Shock ResponseHeat Stress DisordersKidneyAnimalsCatalaseCreatinineInterleukin-1betaMaleMalondialdehydeOxidative StressRatsRats, WistarAnti-Inflammatory AgentsAntioxidantsAntipyrineCatalaseCreatinineEdaravoneInterleukin-1betaMalondialdehydeTumor Necrosis Factor-alphaEdaravoneHeat-stressKidney histopathologyKidney tissueOxidative stressProinflammatory biomarkers

Identifiers

PMID39625491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.