Evidence map›Paper›PMID 39625457›Full record

ArticleInorganic chemistry2024

Rings of Power: Controlling SOD Mimic Activity by the Addition of Pyridine Rings within the Pyridinophane Scaffold.

Katherine J Smith, Timothy M Schwartz, David M Freire, Cameron J Bowers, Sarah K Dunn, Jackson F Bonnell, Magy A Mekhail, Giridhar Akkaraju, Kayla N Green

Abstract read
In one paragraph

Article in Inorganic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Pd-decorated CuO/g-CRSC advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine J SmithDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.
Timothy M SchwartzDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.ORCID 0000-0002-9070-6810
David M FreireDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.ORCID 0000-0002-0976-2680
Cameron J BowersDepartment of Biology, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.
Sarah K DunnDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.
Jackson F BonnellDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.
Magy A MekhailDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.
Giridhar AkkarajuDepartment of Biology, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.
Kayla N GreenDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, Texas 76129, United States.ORCID 0000-0001-8816-7646

Funding

Targeting oxidative stress in neurodegeneration using pyridol-derived small moleculesR15GM123463 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI AKKARAJU, GIRIDHAR, CHUMLEY, MICHAEL J · 2018 to 2025
$1.2M
NIGMS NIH HHS R15 GM123463
6 · The paper itself

Abstract

Superoxide dismutase enzymes are a major defense against superoxide, which is a potent reactive oxygen species. Misregulation of reactive oxygen species and subsequent neuronal damage are etiological hallmarks of neurodegenerative disease. Macrocyclic small molecules have offered inroads toward functional SOD1 mimics. Herein, we report a series of five tetra-aza macrocyclic

Indexed as

PyridinesBiomimetic MaterialsCoordination ComplexesCopperHumansLigandsMolecular StructureSuperoxide DismutaseCoordination ComplexesCopperLigandspyridinePyridinesSuperoxide Dismutase

Identifiers

PMID39625457
PMCPMC11896210

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.