Evidence map›Paper›PMID 39625398›Full record

ArticleAging2024

Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry.

Kazuto Aono, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Yukari Maeda, Hisaya Kato, Yoshiro Maezawa, Makoto Miyabayashi, Mai Ishikawa, Akiko Sekiguchi and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Kazuto AonoDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Masaya KoshizakaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Mayumi ShojiDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Hiyori KanekoDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Yukari MaedaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Hisaya KatoDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Yoshiro MaezawaDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Makoto MiyabayashiDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Mai IshikawaDepartment of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Akiko SekiguchiDepartment of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Sei-Ichiro MotegiDepartment of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Shinji TsukamotoDepartment of Orthopaedic Surgery, Nara Medical University, Nara, Japan.
Akira TaniguchiDepartment of Orthopaedic Surgery, Nara Medical University, Nara, Japan.
Yukiko ShodaDepartment of Dermatology, Sumitomo Hospital, Osaka, Japan.
Toru YoshimuraDiabetes and Endocrinology, Saga-Ken Medical Centre Koseikan, Saga, Japan.
Junji KawashimaDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kayo YoshinagaDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hironori NakagamiDepartment of Health Development and Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Yoichi TakamiDepartment of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Ken SugimotoGeneral Geriatric Medicine, Kawasaki Medical School, Okayama, Japan.
Kunihiko HashimotoDepartment of Endocrinology and Metabolic Medicine, Nippon Life Hospital, Osaka, Japan.
Naoki OkuboDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Takashi YoshidaDepartment of Orthopaedic Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Masato OharaDepartment of Orthopaedic Surgery, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Asako KogureDepartment of Dermatology, Showa General Hospital, Tokyo, Japan.
Daisuke SuzukiDepartment of Dermatology, Showa General Hospital, Tokyo, Japan.
Masafumi KuzuyaGeriatrics and General Internal Medicine, Meitetsu Hospital, Nagoya, Japan.
Kazuhisa WatanabeDepartment of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Minoru TakemotoDepartment of Medicine, Division of Diabetes, Metabolism and Endocrinology, International University of Health and Welfare, Narita, Japan.
Junko OshimaDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.
Koutaro YokoteDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.

Funding

International Registry of Werner SyndromeR01CA210916 · NCI · UNIVERSITY OF WASHINGTON · PI JUNKO OSHIMA · 2016 to 2026
$3.8M
NCI NIH HHS R01 CA210916
6 · The paper itself

Abstract

BACKGROUND AND

aimWerner syndrome (WS) is an autosomal recessive, adult-onset, progeroid syndrome caused by

methodsWe analyzed the data of 51 patients with WS enrolled in the Japanese Werner Syndrome Registry between 2016 and 2022. A cross-sectional analysis was performed to determine the association with skin ulcers at baseline. Statistical analyses were conducted, including Welch's and Pearson's chi-square tests. Age was adjusted using a logistic regression model.

resultsThe mean patient age was 48.8±7.6 years, and 66.7% of patients presented with skin ulcers. Univariate analysis showed that patients with skin ulcers were older than those without ulcers. Systolic blood pressure (SBP) was higher in patients with skin ulcers. Patients without skin ulcers received metformin and pioglitazone treatment significantly more often than those with ulcers. Logistic regression analysis adjusted for age showed that higher SBP remained a significant risk factor for skin ulcers. Patients administered pioglitazone had lower ulcer morbidity.

conclusionsAge and SBP are risk factors for skin ulcers in patients with WS. Moreover, pioglitazone treatment may prevent skin ulcers.

Indexed as

PioglitazoneRegistriesSkin UlcerWerner SyndromeAdultBlood PressureCross-Sectional StudiesEast Asian PeopleFemaleHumansHypoglycemic AgentsJapanMaleMiddle AgedRisk FactorsHypoglycemic AgentsPioglitazonemetforminpioglitazonprogeroid syndromeskin ulcerWerner syndrome

Identifiers

PMID39625398
PMCPMC11723649

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.