Evidence map›Paper›PMID 39625259›Full record

ArticleTissue barriers2025

Mechanical stiffness across skin layers in human: a pilot study.

Wan-Yu Chi, Hao-Wei Huang, Gang-Hui Lee, Criselda Jean G Cruz, Michael W Hughes, Ming-Jer Tang, Shyh-Jou Shieh, Chao-Chun Yang

Abstract read
In one paragraph

Article in Tissue barriers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wan-Yu ChiDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0003-3069-3111
Hao-Wei HuangDivision of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Gang-Hui LeeInternational Center for Wound Repair & Regeneration, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-1428-1611
Criselda Jean G CruzDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-1322-3321
Michael W HughesInternational Center for Wound Repair & Regeneration, National Cheng Kung University, Tainan, Taiwan.
Ming-Jer TangInternational Center for Wound Repair & Regeneration, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-0883-4363
Shyh-Jou ShiehInternational Center for Wound Repair & Regeneration, National Cheng Kung University, Tainan, Taiwan.
Chao-Chun YangDepartment of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-3897-6522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanobiological forces play a pivotal role in the processes of skin homeostasis, wound healing and regeneration. Changes in tissue stiffness are linked to various skin diseases. Using atomic force microscopy, we analyzed the elastic modulus, representing mechanical stiffness, of different skin layers in a group of six participants, including 2 males and 4 females, aged between 1 and 70 years. The skin layers, ranked from highest to lowest elastic modulus, are the epidermis, papillary dermis, upper reticular dermis, lower reticular dermis, sebaceous gland, and subcutaneous tissue. This study contributes to more understanding of the physical properties of the skin, offering a reference for further research on skin physiology or pathology.

Indexed as

SkinSkin Physiological PhenomenaAdolescentAdultAgedChildChild, PreschoolElastic ModulusFemaleHumansInfantMaleMicroscopy, Atomic ForceMiddle AgedPilot ProjectsYoung AdultAtomic force microscopyelastic modulusmechanobiologyskin diseasesskin homeostasisskin stiffness

Identifiers

PMID39625259
PMCPMC12477866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.