ArticleMedical physics2025
Direct minimization of normal-tissue toxicity via an NTCP-based IMPT planning method.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Optimizing allocation of limited proton fractions via NTCP-optimized combined proton-photon radiotherapy.Physical and engineering sciences in medicine · 2026Article
- Dose optimization with fully flexible vertex positioning for LATTICE radiotherapy.Medical physics · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundIntensity-modulated proton therapy (IMPT) planning often relies on physical dose constraints to balance tumor control and sparing of organs at risk (OARs). However, focusing solely on these dose objectives does not always minimize the normal-tissue toxicity, which is quantified as normal tissue complication probability (NTCP). NTCP is also a quantitative criterion for patient selection between proton and photon treatments. PURPOSE: This study introduces an NTCP-based IMPT planning (NTCP-IMPT) method designed to directly minimize normal-tissue toxicity while maintaining tumor coverage.
methodsNTCP-IMPT simultaneously optimizes NTCP and dose-volume histogram (DVH)-based physical dose objectives while adhering to the minimum-monitor-unit (MMU) constraint for plan deliverability. The optimization problem is solved by the interior-point method. To assess its efficacy in reducing normal-tissue toxicity, NTCP-IMPT is compared with standard IMPT (without NTCP optimization) for four head-and-neck (HN) cancer patients in terms of physical dose quality and NTCP of xerostomia and dysphagia.
resultsAcross all four patients, NTCP-IMPT plans met target dose criteria (D
conclusionsNTCP-IMPT effectively minimizes normal-tissue toxicity and improves the sparing of OARs associated with side effects while maintaining comparable tumor coverage compared to standard IMPT.
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